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Literature summary extracted from

  • Rilling, H.C.
    Dimethylallylpyrophosphate: L-tryptophan dimethylallyltransferase (1985), Methods Enzymol., 110, 335-340.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.34
-
 Claviceps sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.34 1,10-phenanthroline
-
 Claviceps sp.
2.5.1.34 2,2'-bipyridyl
-
 Claviceps sp.
2.5.1.34 8-hydroxyquinoline
-
 Claviceps sp.
2.5.1.34 8-mercaptoquinoline
-
 Claviceps sp.
2.5.1.34 Acetylacetone
-
 Claviceps sp.
2.5.1.34 Ca2+ 30 mM inhibits Claviceps sp.
2.5.1.34 Chelating agents in presence of excess of Ca2+ Claviceps sp.
2.5.1.34 dithiothreitol
-
 Claviceps sp.
2.5.1.34 EDTA
-
 Claviceps sp.
2.5.1.34 nitrilotriacetic acid
-
 Claviceps sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.34 additional information
-
 additional information
-
 Claviceps sp.
2.5.1.34 0.007
-
 dimethylallyl diphosphate in presence of Ca2+ Claviceps sp.
2.5.1.34 0.009
-
 tryptophan in presence of Ca2+ Claviceps sp.

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.34 additional information enzyme contains a divalent cation which is most likely involved in catalysis Claviceps sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.34 dimethylallyl diphosphate + L-tryptophan Claviceps sp. first pathway-specific enzyme of ergot alkaloid biosynthesis diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
-
 ?
2.5.1.34 dimethylallyl diphosphate + L-tryptophan Claviceps sp. SD58 first pathway-specific enzyme of ergot alkaloid biosynthesis diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.34 Claviceps sp.
-
 SD58
-
2.5.1.34 Claviceps sp. SD58
-
 SD58
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.34
-
 Claviceps sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.34 mycelium
-
 Claviceps sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.34 0.35
-
-
 Claviceps sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.34 dimethylallyl diphosphate + L-tryptophan
-
 Claviceps sp. diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
-
 ?
2.5.1.34 dimethylallyl diphosphate + L-tryptophan first pathway-specific enzyme of ergot alkaloid biosynthesis Claviceps sp. diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
-
 ?
2.5.1.34 dimethylallyl diphosphate + L-tryptophan
-
 Claviceps sp. SD58 diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
-
 ?
2.5.1.34 dimethylallyl diphosphate + L-tryptophan first pathway-specific enzyme of ergot alkaloid biosynthesis Claviceps sp. SD58 diphosphate + L-4-(gamma,gamma-dimethylallyl)tryptophan
-
 ?