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Literature summary extracted from

  • Guggenheim, S.; Flavin, M.
    Cystathionine gamma-synthase. A pyridoxal phosphate enzyme catalyzing rapid exchanges of beta and alpha hydrogen atoms in amino acids (1969), J. Biol. Chem., 244, 6217-6227.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.48 L-cysteine inhibition of beta-elimination Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.48 O-succinyl-L-homoserine + L-cysteine Salmonella enterica subsp. enterica serovar Typhimurium essential step in bacterial methionine biosynthesis L-cystathionine + succinate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.48 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.48 10.5
-
 O-succinyl-L-homoserine + L-cysteine, gamma-replacement reaction Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.48 L-cystathionine + H2O beta-elimination Salmonella enterica subsp. enterica serovar Typhimurium L-homocysteine + NH3 + pyruvate
-
 ?
2.5.1.48 L-cystathionine + H2O beta-elimination Salmonella enterica subsp. enterica serovar Typhimurium L-cysteine + NH3 + 2-oxobutyrate
-
 ?
2.5.1.48 L-cystathionine + L-cysteine
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-cystathionine + L-cysteine observed via 35S-exchange ?
2.5.1.48 O-succinyl-L-homoserine + H2O gamma-elimination, in absence of L-cysteine Salmonella enterica subsp. enterica serovar Typhimurium succinate + 2-oxobutyrate + NH3
-
 ?
2.5.1.48 O-succinyl-L-homoserine + L-cysteine
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-cystathionine + succinate
-
 ?
2.5.1.48 O-succinyl-L-homoserine + L-cysteine essential step in bacterial methionine biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium L-cystathionine + succinate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.48 pyridoxal 5'-phosphate Km: 0.00004 mM Salmonella enterica subsp. enterica serovar Typhimurium