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Literature summary extracted from

  • Williams, J.W.; Northrop, D.B.
    Kinetic mechanisms of gentamicin acetyltransferase I. Antibiotic-dependent shift from rapid to nonrapid equilibrium random mechanisms (1978), J. Biol. Chem., 253, 5902-5907.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.81 acetyltobramycin
-
 Escherichia coli
2.3.1.81 amikacin
-
 Escherichia coli
2.3.1.81 butyryl-CoA dead-end inhibition pattern Escherichia coli
2.3.1.81 CoA product inhibition Escherichia coli
2.3.1.81 gentamicin C1a substrate inhibition Escherichia coli
2.3.1.81 additional information inhibition kinetics Escherichia coli
2.3.1.81 N3-Acetyltobramycin product inhibition Escherichia coli
2.3.1.81 neomycin
-
 Escherichia coli
2.3.1.81 ribostamycin
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.81 additional information
-
 additional information kinetic pattern Escherichia coli
2.3.1.81 0.00012
-
 gentamicin C1a
-
 Escherichia coli
2.3.1.81 0.0013
-
 acetyl-CoA cosubstrate gentamicin C1a Escherichia coli
2.3.1.81 0.0016
-
 tobramycin
-
 Escherichia coli
2.3.1.81 0.0017
-
 acetyl-CoA cosubstrate tobramycin Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.81 Escherichia coli
-
 containing R-factor JR88
-
2.3.1.81 Escherichia coli C600
-
 containing R-factor JR88
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.81 acetyl-CoA + gentamicin C1a
-
 Escherichia coli CoA + N3'-acetylgentamicin C1a
-
 ?
2.3.1.81 acetyl-CoA + gentamicin C1a
-
 Escherichia coli C600 CoA + N3'-acetylgentamicin C1a
-
 ?
2.3.1.81 acetyl-CoA + sisomicin
-
 Escherichia coli CoA + N3'-acetylsisomicin
-
 ?
2.3.1.81 acetyl-CoA + sisomicin
-
 Escherichia coli C600 CoA + N3'-acetylsisomicin
-
 ?
2.3.1.81 acetyl-CoA + tobramycin
-
 Escherichia coli CoA + N3'-acetyltobramycin
-
 ?
2.3.1.81 acetyl-CoA + tobramycin
-
 Escherichia coli C600 CoA + N3'-acetyltobramycin
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.81 25
-
 assay at Escherichia coli