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Literature summary extracted from

  • Fast, D.G.; Jamieson, J.C.; McCaffrey, G.
    The role of the carbohydrate chains of Gal beta-1,4-GlcNAc alpha 2,6-sialyltransferase for enzyme activity (1993), Biochim. Biophys. Acta, 1202, 325-330.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.1 endo F inactivation due to deglycosylation of the enzyme, best in methanol or ethanol, less efficient than glycanase Rattus norvegicus
2.4.3.1 glycanase inactivation due to deglycosylation of the enzyme, best in methanol or ethanol Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.1 Golgi apparatus membrane-bound at the luminal side, trans compartment Rattus norvegicus 5794
-
2.4.3.1 Golgi trans face
-
 Rattus norvegicus
-
-
2.4.3.1 membrane
-
 Rattus norvegicus 16020
-
2.4.3.1 additional information enzyme is not catalytically active in the endoplasmic reticulum and only achieves full activity when it locates itself to the trans compartment of the Golgi system Rattus norvegicus
-
-

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
2.4.3.1 Methanol stable at 10%, 37°C Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.1 Rattus norvegicus
-
 purified enzyme
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.3.1 glycoprotein contains at least 2 N-linked carbohydate chains of the complex type Rattus norvegicus
2.4.3.1 glycoprotein catalytic activity of the enzyme depends on the presence of oligosaccharide chains Rattus norvegicus
2.4.3.1 additional information deglycosylation of the enzyme is much more efficient in presence of methanol or ethanol Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R sialic acid is linked to C-6 of the galactose residue Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.1 Galbeta1,4-GlcNAc alpha2,6 sialyltransferase
-
 Rattus norvegicus