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Literature summary extracted from

  • Giladi, M.; Bitan-Banin, G.; Mevarech, M.; Ortenberg, R.
    Genetic evidence for a novel thymidylate synthase in the halophilic archaeon Halobacterium salinarum and in Campylobacter jejuni (2002), FEMS Microbiol. Lett., 216, 105-109.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.148 complemetation of Escherichia coli thyA deletion mutant, transformants are able to grow in the absence of thymidine under oxygen limited conditions Campylobacter jejuni
2.1.1.148 complemetation of Haloferax volcanii thyA deletion mutant, transformants are able to grow in the absence of thymidine Halobacterium salinarum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.148 O2
-
 Campylobacter jejuni

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.148 23800
-
 SDS-PAGE Campylobacter jejuni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.148 5,10-methylenetetrahydrofolate + dUMP + FADH2 Halobacterium salinarum
-
 dTMP + tetrahydrofolate + FAD
-
 ?
2.1.1.148 5,10-methylenetetrahydrofolate + dUMP + FADH2 Campylobacter jejuni
-
 dTMP + tetrahydrofolate + FAD
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.148 Campylobacter jejuni
-
-
-
2.1.1.148 Halobacterium salinarum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.148 from transformed E. coli Campylobacter jejuni

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.148 5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Halobacterium salinarum dTMP + tetrahydrofolate + FAD
-
 ?
2.1.1.148 5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Campylobacter jejuni dTMP + tetrahydrofolate + FAD
-
 ?