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Literature summary extracted from

  • Kaneko, M.; Fujimoto, S.; Kikugawa, M.; Tamaki, N.
    Irreversible inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by gabaculine (1990), FEBS Lett., 276, 115-118.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 gabaculine
-
 Rattus norvegicus
2.6.1.40 gabaculine i.e. 5-amino-1,3-cyclohexadienylcarboxylate, strong, irreversible, beta-alanine or pyruvate protects, 4-aminobutyrate to a lesser extent, not 2-oxoglutarate Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.19 additional information
-
 additional information
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Rattus norvegicus
-
-
-
2.6.1.40 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 liver
-
 Rattus norvegicus
-
2.6.1.40 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Rattus norvegicus 4-oxobutanoate + L-glutamate
-
 r
2.6.1.19 beta-alanine + 2-oxoglutarate
-
 Rattus norvegicus malonic semialdehyde + L-glutamate
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.40 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.19 pyridoxal 5'-phosphate
-
 Rattus norvegicus
2.6.1.40 pyridoxal 5'-phosphate
-
 Rattus norvegicus