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Literature summary extracted from

  • Tamaki, N.; Fujimoto, S.; Mizota, C.; Kikugawa, M.
    Identity of beta-alanine-oxo-glutarate aminotransferase and L-beta-aminoisobutyrate aminotransferase in rat liver (1987), Biochim. Biophys. Acta, 925, 238-240.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.22 (S)-3-amino-2-methylpropanoate beta-alanine as substrate, not (R)-isomer Rattus norvegicus
2.6.1.22 Antiserum against beta-alanine:2-oxoglutarate aminotransferase
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.19 1.05
-
 beta-Alanine
-
 Rattus norvegicus
2.6.1.19 2.72
-
 L-3-aminoisobutanoate
-
 Rattus norvegicus
2.6.1.22 2.7
-
 (S)-3-amino-2-methylpropanoate pH 8.8, 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.22 cytoplasm
-
 Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.22 (S)-3-amino-2-methylpropanoate + 2-oxoglutarate Rattus norvegicus involved in omega-amino acid metabolism in mammals 2-methyl-3-oxopropanoate + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Rattus norvegicus
-
-
-
2.6.1.22 Rattus norvegicus
-
 male Sprague Dawley
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.22 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 liver
-
 Rattus norvegicus
-
2.6.1.22 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Rattus norvegicus 4-oxobutanoate + L-glutamate
-
 r
2.6.1.19 beta-alanine + 2-oxoglutarate
-
 Rattus norvegicus malonic semialdehyde + L-glutamate
-
 ?
2.6.1.19 L-3-aminoisobutanoate + 2-oxoglutarate
-
 Rattus norvegicus ?
-
 ?
2.6.1.22 (S)-3-amino-2-methylpropanoate + 2-oxoglutarate i.e. L-beta-aminoisobutyrate, not D-isomer Rattus norvegicus 2-methyl-3-oxopropanoate + L-glutamate
-
 ?
2.6.1.22 (S)-3-amino-2-methylpropanoate + 2-oxoglutarate involved in omega-amino acid metabolism in mammals Rattus norvegicus 2-methyl-3-oxopropanoate + L-glutamate
-
 ?
2.6.1.22 beta-alanine + 2-oxoglutarate as good as (S)-3-amino-2-methylpropanoate Rattus norvegicus malonic semialdehyde + L-glutamate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.22 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.19 pyridoxal 5'-phosphate
-
 Rattus norvegicus
2.6.1.22 pyridoxal 5'-phosphate
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.22 2.7
-
 (S)-3-amino-2-methylpropanoate pH 8.8, 37°C Rattus norvegicus