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Literature summary extracted from

  • Kakimoto, Y.; Kanazawa, A.; Taniguchi, K.; Sano, I.
    beta-Aminoisobutyrate-alpha-ketoglutarate transaminase in relation to beta-aminoisobutyric aciduria (1968), Biochim. Biophys. Acta, 156, 374-380.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.22 2-oxoglutarate in excess, substrate inhibition Sus scrofa
2.6.1.22 pyridoxal 5'-phosphate inhibits at high concentrations, activates at low concentrations Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.22 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.22
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.22 kidney
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.22 0.185
-
 pH 7.5, 37°C Sus scrofa

Storage Stability

EC Number Storage Stability Organism
2.6.1.22 -20°C, in 0.05 M phosphate buffer, pH 7.5, at least 3 weeks Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.22 (S)-3-amino-2-methylpropanoate + 2-oxoglutarate i.e. L-beta-aminoisobutyrate, not D-isomer Sus scrofa 2-methyl-3-oxopropanoate + L-glutamate
-
 r
2.6.1.22 4-aminobutanoate + 2-oxoglutarate transamination at 92% the rate of (S)-3-amino-2-methylpropanoate Sus scrofa succinic semialdehyde + L-glutamate
-
 ?
2.6.1.22 5-aminopentanoate + 2-oxoglutarate transamination at 33% the rate of (S)-3-amino-2-methylpropanoate Sus scrofa 5-oxopentanoate + L-glutamate
-
 ?
2.6.1.22 beta-alanine + 2-oxoglutarate as good as (S)-3-amino-2-methylpropanoate Sus scrofa malonic semialdehyde + L-glutamate
-
 ?
2.6.1.22 additional information no substrates are 3-aminobutanoate, 2-ethyl-beta-alanine, glycine, L-alpha-alanine, 2-aminoisobutanoate, lysine, taurine, O-phosphoethanolamine, homocarnosine. Poor substrates are 6-aminohexanoate or ornithine, no substrates are pyruvate, oxaloacetate or glyoxylate Sus scrofa ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.22 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.22 9.1
-
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.6.1.22 8.5 9.5 about half-maximal activity at pH 8.5 and 9.5 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.22 pyridoxal 5'-phosphate activates at low concentrations, inhibits at high concentrations Sus scrofa