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Literature summary extracted from

  • Chavideh, R.; Sholly, S.; Panaite, D.; Tolmasky, M.E.
    Effects of F171 mutations in the 6'-N-acetyltransferase type Ib [AAC(6')-Ib] enzyme on susceptibility to aminoglycosides (1999), Antimicrob. Agents Chemother., 43, 2811-2812.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.82 F171G the mutant enzyme is unable to confer resistance against amikacin, kanamycin, netilmicin and tobramicin Klebsiella pneumoniae
2.3.1.82 F171I the mutant enzyme shows reduced resistance against amikacin, kanamycin, netilmicin and tobramicin Klebsiella pneumoniae
2.3.1.82 F171K the mutant enzyme is unable to confer resistance against amikacin, kanamycin, netilmicin and tobramicin Klebsiella pneumoniae
2.3.1.82 F171L the mutant enzyme shows reduced resistance against amikacin, kanamycin, netilmicin and tobramicin Klebsiella pneumoniae
2.3.1.82 F171M the mutant enzyme is able to confer detectable resistance against amikacin, kanamycin, netilmicin and tobramicin, although the levels are considerably lower than those conferred by the wild-type enzyme Klebsiella pneumoniae
2.3.1.82 F171N the mutant enzyme is unable to confer resistance against amikacin, kanamycin, netilmicin and tobramicin Klebsiella pneumoniae
2.3.1.82 F171S the mutant enzyme is unable to confer resistance against amikacin, kanamycin, netilmicin and tobramicin Klebsiella pneumoniae
2.3.1.82 F171W the mutant enzyme is able to confer detectable resistance against amikacin, kanamycin, netilmicin and tobramicin, although the levels are considerably lower than those conferred by the wild-type enzyme Klebsiella pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.82 additional information Klebsiella pneumoniae involved in resistance to antibiotics ?
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Organism

EC Number Organism UniProt Comment Textmining
2.3.1.82 Klebsiella pneumoniae
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.82 acetyl-CoA + amikacin wild-type enzyme shows activity, mutant enzymes show no activity or reduced activity Klebsiella pneumoniae CoA + N6'-acetylamikacin
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 ?
2.3.1.82 acetyl-CoA + kanamycin wild-type enzyme shows activity, mutant enzymes show no activity or reduced activity Klebsiella pneumoniae CoA + N6'-acetylkanamycin
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 ?
2.3.1.82 acetyl-CoA + netilmicin wild-type enzyme shows activity, mutant enzymes show no activity or reduced activity Klebsiella pneumoniae CoA + N6'-acetylnetilmicin
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 ?
2.3.1.82 acetyl-CoA + tobramycin wild-type enzyme shows activity, mutant enzymes show no activity or reduced activity Klebsiella pneumoniae CoA + N6'-acetyltobramycin
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 ?
2.3.1.82 additional information involved in resistance to antibiotics Klebsiella pneumoniae ?
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 ?