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Literature summary extracted from

  • Marcos, N.T.; Cruz, A.; Silva, F.; Almeida, R.; David, L.; Mandel, U.; Clausen, H.; von Mensdorff-Pouilly, S.; Reis, C.A.
    Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines (2003), J. Histochem. Cytochem., 51, 761-771.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.3 CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein Homo sapiens ST6GalNAc-I is responsible for the synthesis of Sialyl-Tn antigen, Neu5Acalpha(2-6)GalNAc, synthesis of Sialyl-Tn structures in mucin O-glycosylation stops further processing and elongation of the carbohydrate chain CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.41 Homo sapiens
-
-
-
2.4.3.3 Homo sapiens
-
 ST6GalNAc-I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.41 gastric cancer cell line human diffuse gastric carcinoma cell line GP202, enzyme form GalNAc-T1 Homo sapiens
-
2.4.1.41 gastric cancer cell line human diffuse gastric carcinoma cell line GP202, enzyme form GalNAc-T2 Homo sapiens
-
2.4.1.41 gastric cancer cell line human diffuse gastric carcinoma cell line GP202, enzyme form GalNAc-T3 Homo sapiens
-
2.4.1.41 gastric cancer cell line human diffuse gastric carcinoma cell line GP220, enzyme form GalNAc-T1 Homo sapiens
-
2.4.1.41 gastric cancer cell line human diffuse gastric carcinoma cell line GP220, enzyme form GalNAc-T2 Homo sapiens
-
2.4.1.41 gastric cancer cell line human diffuse gastric carcinoma cell line GP220, enzyme form GalNAc-T3 Homo sapiens
-
2.4.1.41 gastric cancer cell line human diffuse gastric carcinoma cell line GP220, enzyme form GalNAc-T4 Homo sapiens
-
2.4.1.41 HT-29 cell enzyme form GalNAc-T1 Homo sapiens
-
2.4.1.41 HT-29 cell enzyme form GalNAc-T2 Homo sapiens
-
2.4.1.41 HT-29 cell enzyme form GalNAc-T3 Homo sapiens
-
2.4.1.41 HT-29 cell low activity, enzyme form GalNAc-T4 Homo sapiens
-
2.4.1.41 HT-29 cell low activity, enzyme form GalNAc-T6 Homo sapiens
-
2.4.1.41 K-562 cell enzyme form GalNAc-T1 Homo sapiens
-
2.4.1.41 K-562 cell enzyme form GalNAc-T3 Homo sapiens
-
2.4.1.41 K-562 cell human trophoblast, enzyme form GalNAc-T1 Homo sapiens
-
2.4.1.41 K-562 cell low activity, enzyme form GalNAc-T11 Homo sapiens
-
2.4.1.41 K-562 cell low activity, enzyme form GalNAc-T4 Homo sapiens
-
2.4.1.41 KATO-III cell enzyme form GalNAc-T11 Homo sapiens
-
2.4.1.41 KATO-III cell enzyme form GalNAc-T3 Homo sapiens
-
2.4.1.41 KATO-III cell enzyme form GalNAc-T4 Homo sapiens
-
2.4.1.41 KATO-III cell enzyme form GalNAc-T6 Homo sapiens
-
2.4.1.41 KATO-III cell human stomach cancer, enzyme form GalNAc-T1 Homo sapiens
-
2.4.1.41 KATO-III cell human stomach cancer, enzyme form GalNAc-T2 Homo sapiens
-
2.4.1.41 MKN-45 cell enzyme form GalNAc-T3 Homo sapiens
-
2.4.1.41 MKN-45 cell human colon epithelial carcinoma, enzyme form GalNAc-T1 Homo sapiens
-
2.4.1.41 MKN-45 cell human colon epithelial carcinoma, enzyme form GalNAc-T2 Homo sapiens
-
2.4.1.41 MKN-45 cell low activity, enzyme form GalNAc-T11 Homo sapiens
-
2.4.1.41 MKN-45 cell low activity, enzyme form GalNAc-T4 Homo sapiens
-
2.4.1.41 additional information no activity of GalNAc-T4 in GP202 cells Homo sapiens
-
2.4.1.41 additional information no activity of GalNAc-T6 in GP202 cells and GP220 cells Homo sapiens
-
2.4.1.41 additional information no activity of GalNAc-T6 in MKN45 cells, GP202 cells, GP220 cells, and K562 Homo sapiens
-
2.4.3.3 K-562 cell hematopoietic cell line, high ST6GalNAc-I expression Homo sapiens
-
2.4.3.3 additional information low expression of ST6GalNAc-I in gastric carcinoma cell lines MKN45, KATO-III, GP202 and GP220, correlating with very low or absent detection of the Sialyl-Tn antigen Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.3 CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein ST6GalNAc-I is responsible for the synthesis of Sialyl-Tn antigen, Neu5Acalpha(2-6)GalNAc, synthesis of Sialyl-Tn structures in mucin O-glycosylation stops further processing and elongation of the carbohydrate chain Homo sapiens CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
 ?
2.4.3.3 CMP-N-acetylneuraminate + R-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
-
 Homo sapiens CMP + R-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.41 GalNAc-T1
-
 Homo sapiens
2.4.1.41 GalNAc-T11
-
 Homo sapiens
2.4.1.41 GalNAc-T2
-
 Homo sapiens
2.4.1.41 GalNAc-T3
-
 Homo sapiens
2.4.1.41 GalNAc-T4
-
 Homo sapiens
2.4.1.41 GalNAc-T6
-
 Homo sapiens