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Literature summary extracted from

  • Paszkowski, A.
    Some properties of serine: glyoxylate aminotransferase from rye seedlings (Secale cereale L.) (1991), Acta Biochim. Pol., 38, 437-448.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.45 Aminooxyacetate competitive inhibition Secale cereale
2.6.1.45 D-serine competitive inhibition Secale cereale
2.6.1.45 formaldehyde glyoxylate protects Secale cereale
2.6.1.45 glyoxylate amino acid substrates partially protect Secale cereale
2.6.1.45 hydroxylamine 0.1 mM, 70% inhibition Secale cereale
2.6.1.45 Isonicotinic acid hydrazide 0.1 mM, 20% inhibition Secale cereale
2.6.1.45 SH-group inhibitor
-
 Secale cereale

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.45 Secale cereale
-
 rye
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.6.1.45 L-serine + glyoxylate = 3-hydroxypyruvate + glycine ping pong bi bi mechanism Secale cereale
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.45 seedling 7 days old Secale cereale
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.45 L-alanine + glyoxylate
-
 Secale cereale pyruvate + glycine
-
 ?
2.6.1.45 L-asparagine + glyoxylate
-
 Secale cereale 2-oxosuccinamate + glycine
-
 ?
2.6.1.45 L-serine + glyoxylate
-
 Secale cereale 3-hydroxypyruvate + glycine
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.45 pyridoxal 5'-phosphate required for activity Secale cereale
2.6.1.45 pyridoxal 5'-phosphate loosely bound Secale cereale

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.45 0.00012
-
 Aminooxyacetate
-
 Secale cereale
2.6.1.45 1.6
-
 D-serine
-
 Secale cereale