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Literature summary extracted from

  • Hearing, V.J.
    Mammalian monophenol monooxygenase (tyrosinase): purification, properties, and reactions catalyzed (1987), Methods Enzymol., 142, 154-165.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.1 L-3,4-dihydroxyphenylalanine + 1/2 O2 Mammalia
-
 L-dopaquinone + H2O
-
 ?
1.14.18.1 L-3,4-dihydroxyphenylalanine + 1/2 O2 Mus musculus
-
 L-dopaquinone + H2O
-
 ?
1.14.18.1 L-tyrosine + O2 + AH2 Mammalia
-
 L-3,4-dihydroxyphenylalanine + H2O + A
-
 ?
1.14.18.1 L-tyrosine + O2 + AH2 Mus musculus
-
 L-3,4-dihydroxyphenylalanine + H2O + A
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Mammalia
-
-
-
1.14.18.1 Mus musculus
-
 B16 melanoma cells
-
1.14.18.1 Mus musculus
-
 isoenzymes T1, T2, T3 and T4
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.14.18.1 glycoprotein
-
 Mus musculus
1.14.18.1 glycoprotein
-
 Mammalia

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.18.1
-
 Mammalia
1.14.18.1 ammonium sulfate, S-300 chromatography, preparative PAGE Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 melanoma cell
-
 Mus musculus
-
1.14.18.1 melanoma cell
-
 Mammalia
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.18.1 additional information
-
 assay methods Mammalia
1.14.18.1 45
-
-
 Mammalia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 4-methylcatechol + O2
-
 Mammalia 4-methyl-o-benzoquinone + H2O
-
 ?
1.14.18.1 4-methylcatechol + O2
-
 Mus musculus 4-methyl-o-benzoquinone + H2O
-
 ?
1.14.18.1 L-3,4-dihydroxyphenylalanine + 1/2 O2
-
 Mammalia L-dopaquinone + H2O
-
 ?
1.14.18.1 L-3,4-dihydroxyphenylalanine + 1/2 O2
-
 Mus musculus L-dopaquinone + H2O
-
 ?
1.14.18.1 L-tyrosine + O2 + AH2
-
 Mammalia L-3,4-dihydroxyphenylalanine + H2O + A
-
 ?
1.14.18.1 L-tyrosine + O2 + AH2
-
 Mus musculus L-3,4-dihydroxyphenylalanine + H2O + A
-
 ?