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Literature summary extracted from

  • Rueffer, M.; El-Shagi, H.; Nagakura, N.; Zenk, M.H.
    (S)-Norlaudanosoline synthase: the first enzyme in the benzylisoquinoline biosynthetic pathway (1981), FEBS Lett., 129, 5-9.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.78 1
-
 3,4-dihydroxyphenylacetaldehyde
-
 Eschscholtzia tenuifolia
4.2.1.78 5
-
 4-(2-Aminoethyl)benzene-1,2-diol
-
 Eschscholtzia tenuifolia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Papaver somniferum initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Berberis regeliana initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Capnoides sempervirens initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Lamprocapnos spectabilis initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Eschscholzia pulchella initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Fumaria officinalis initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Glaucium rubrum initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Meconopsis cambrica initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Ranunculus flammula initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Thalictrum tuberosum initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Eschscholtzia tenuifolia initial reaction in isoquinoline biosynthesis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde Thalictrum minus initial reaction in isoquinoline biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.78 Berberis regeliana
-
-
-
4.2.1.78 Capnoides sempervirens
-
-
-
4.2.1.78 Eschscholtzia tenuifolia
-
-
-
4.2.1.78 Eschscholzia pulchella
-
-
-
4.2.1.78 Fumaria officinalis
-
-
-
4.2.1.78 Glaucium rubrum
-
-
-
4.2.1.78 Lamprocapnos spectabilis
-
-
-
4.2.1.78 Meconopsis cambrica
-
-
-
4.2.1.78 Papaver somniferum
-
-
-
4.2.1.78 Ranunculus flammula
-
-
-
4.2.1.78 Thalictrum minus
-
-
-
4.2.1.78 Thalictrum tuberosum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.78 cell culture
-
 Papaver somniferum
-
4.2.1.78 cell culture
-
 Berberis regeliana
-
4.2.1.78 cell culture
-
 Capnoides sempervirens
-
4.2.1.78 cell culture
-
 Lamprocapnos spectabilis
-
4.2.1.78 cell culture
-
 Eschscholzia pulchella
-
4.2.1.78 cell culture
-
 Fumaria officinalis
-
4.2.1.78 cell culture
-
 Glaucium rubrum
-
4.2.1.78 cell culture
-
 Meconopsis cambrica
-
4.2.1.78 cell culture
-
 Ranunculus flammula
-
4.2.1.78 cell culture
-
 Thalictrum tuberosum
-
4.2.1.78 cell culture
-
 Eschscholtzia tenuifolia
-
4.2.1.78 cell culture
-
 Thalictrum minus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Papaver somniferum (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Berberis regeliana (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Capnoides sempervirens (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Lamprocapnos spectabilis (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Eschscholzia pulchella (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Fumaria officinalis (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Glaucium rubrum (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Meconopsis cambrica (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Ranunculus flammula (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Thalictrum tuberosum (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
-
 Thalictrum minus (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde i.e. dopamine + 3,4-dihydroxyphenylacetaldehyde, , 3,4-dihydroxyphenylacetaldehyde can be substituted by 4-hydroxyphenylacetaldehyde but not by 3,4-dihydroxyphenylpyruvate, 4-hydroxyphenylpyruvate or phenylpyruvate Eschscholtzia tenuifolia (S)-norlaudanosoline + H2O
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde i.e. dopamine + 4-hydroxyphenylacetaldehyde, , 4-hydroxyphenylacetaldehyde can be substituted by 3,4-dihydroxyphenylacetaldehyde but not by 3,4-dihydroxyphenylpyruvate, 4-hydroxyphenylpyruvate or phenylpyruvate Eschscholtzia tenuifolia (S)-Norcoclaurine + H2O
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Papaver somniferum ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Berberis regeliana ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Capnoides sempervirens ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Lamprocapnos spectabilis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Eschscholzia pulchella ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Fumaria officinalis ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Glaucium rubrum ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Meconopsis cambrica ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Ranunculus flammula ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Thalictrum tuberosum ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Eschscholtzia tenuifolia ?
-
 ?
4.2.1.78 4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde initial reaction in isoquinoline biosynthesis Thalictrum minus ?
-
 ?

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.2.1.78 5.5 8.5
-
 Eschscholtzia tenuifolia