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Literature summary extracted from

  • Yusuf, H.K.M.; Schwarzmann, G.; Pohlentz, G.; Sandhoff, K.
    Oligosialogangliosides inhibit GM2- and GD3-synthesis in isolated Golgi vesicles from rat liver (1987), Biol. Chem. Hoppe-Seyler, 368, 455-462.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.92 Detergents requirement, solubilized enzyme, e.g. Triton X-100 Rattus norvegicus
2.4.1.92 octylglucoside activation Rattus norvegicus
2.4.1.92 phosphatidylglycerol activation, detergent-free assay Rattus norvegicus
2.4.1.92 Triton X-100
-
 Rattus norvegicus
2.4.3.8 additional information the presence of detergents is essential for activity, no activation by phosphatidylglycerol Rattus norvegicus
2.4.3.8 Triton X-100
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.92 ganglioside GD1a
-
 Rattus norvegicus
2.4.1.92 ganglioside GM1
-
 Rattus norvegicus
2.4.1.92 ganglioside GM2
-
 Rattus norvegicus
2.4.1.92 ganglioside GQ1b not in detergent-solubilized enzyme assays, kinetics Rattus norvegicus
2.4.1.92 ganglioside GT1b
-
 Rattus norvegicus
2.4.3.8 ganglioside D1a
-
 Rattus norvegicus
2.4.3.8 Ganglioside Q1b strong Rattus norvegicus
2.4.3.8 Ganglioside T1b
-
 Rattus norvegicus
2.4.3.8 additional information no inhibition by ganglioside GM2 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.92 Golgi apparatus
-
 Rattus norvegicus 5794
-
2.4.3.8 Golgi apparatus
-
 Rattus norvegicus 5794
-
2.4.3.8 membrane
-
 Rattus norvegicus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.92 Rattus norvegicus
-
-
-
2.4.3.8 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.92 liver
-
 Rattus norvegicus
-
2.4.3.8 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.92 UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
-
 Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM2(N-acetylneuraminic acid)-ganglioside ?
2.4.3.8 CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide i.e. disialosyllactosylceramide or ganglioside GD3 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.92 37
-
 assay at Rattus norvegicus
2.4.3.8 37
-
 assay at Rattus norvegicus