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Literature summary extracted from

  • Griffiths, J.S.; Wymer, N.J.; Njolito, E.; Niranjanakumari, S.; Fierke, C.A.; Toone, E.J.
    Cloning, Isolation and Characterization of the Thermotoga Maritima KDPG aldolase (2002), Bioorg. Med. Chem., 10, 545-550.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.2.14 expressed in Escherichia coli Thermotoga maritima

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.2.14 0.2
-
 2-dehydro-3-deoxy-D-gluconate 6-phosphate
-
 Thermotoga maritima
4.1.2.14 0.22
-
 2-dehydro-3-deoxy-D-gluconate 6-phosphate pH 7.5, 40°C Thermotoga maritima
4.1.2.14 0.9
-
 2-dehydro-3-deoxy-D-gluconate 6-phosphate pH 7.5, 70°C Thermotoga maritima

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.14 Thermotoga maritima
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.2.14 9.4
-
-
 Thermotoga maritima

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.14 2-dehydro-3-deoxy-D-gluconate 6-phosphate
-
 Thermotoga maritima pyruvate + D-glyceraldehyde 3-phosphate
-
 r
4.1.2.14 2-oxobutyrate + D-glyceraldehyde weak substrate Thermotoga maritima ?
-
 ?
4.1.2.14 3-fluoropyruvate + D-glyceraldehyde weak substrate Thermotoga maritima ?
-
 ?
4.1.2.14 pyruvate + 2-pyridine carboxaldehyde weak substrate Thermotoga maritima ?
-
 ?
4.1.2.14 pyruvate + D-erythrose weak substrate Thermotoga maritima ?
-
 ?
4.1.2.14 pyruvate + D-threose weak substrate Thermotoga maritima ?
-
 ?
4.1.2.14 pyruvate + glycoaldehyde
-
 Thermotoga maritima ?
-
 ?
4.1.2.14 pyruvate + L-erythrose weak substrate Thermotoga maritima ?
-
 ?
4.1.2.14 pyruvate + L-glyceraldehyde 3-phosphate weak substrate Thermotoga maritima ?
-
 ?
4.1.2.14 pyruvate + L-threose weak substrate Thermotoga maritima ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.2.14 80
-
-
 Thermotoga maritima

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.2.14 0.0333
-
 2-dehydro-3-deoxy-D-gluconate 6-phosphate
-
 Thermotoga maritima
4.1.2.14 2
-
 2-dehydro-3-deoxy-D-gluconate 6-phosphate pH 7.5, 40°C Thermotoga maritima
4.1.2.14 3.9
-
 2-dehydro-3-deoxy-D-gluconate 6-phosphate pH 7.5, 70°C Thermotoga maritima