Any feedback?
Literature summary extracted from
- Stoffwechselprodukte von Mikroorganismen. 114. Mitteilung. Thymidin-diphospho-D-glucose oxidoreduktase aus Streptomyces rimosus (1973), Arch. Mikrobiol., 88, 37-48.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.46 | p-chloromercuribenzoate | - |
Streptomyces rimosus |  |
| 4.2.1.46 | TDP | competitive inhibitor | Streptomyces rimosus | |
| 4.2.1.46 | TMP | competitive inhibitor | Streptomyces rimosus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.46 | 0.093 | - |
dTDPglucose | - |
Streptomyces rimosus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.46 | dTDP-glucose | Streptomyces rimosus | activity increases during stationary growth phase | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.46 | Streptomyces rimosus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.1.46 | - |
Streptomyces rimosus |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.46 | 0.04 | - |
dTDPglucose | Streptomyces rimosus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 4.2.1.46 | 60% loss of activity during storage in 0.025 M potassium phosphate or 0.025 M Tris-HCl at 0¦C for 24 hours, stable for several days at 0¦C and buffer concentrations of 0.25 M or 20% glycerol or 34% sucrose | Streptomyces rimosus |
| 4.2.1.46 | stable for several weeks at -20¦C | Streptomyces rimosus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.46 | dTDP-glucose | - |
Streptomyces rimosus | dTDP-4-dehydro-6-deoxy-D-glucose + H2O | - |
? | |
| 4.2.1.46 | dTDP-glucose | activity increases during stationary growth phase | Streptomyces rimosus | ? | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.46 | 7.2 | - |
dTDPglucose | Streptomyces rimosus |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.46 | 7.5 | 9 | rapid inactivation at acidic pH | Streptomyces rimosus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.46 | NAD+ | - |
Streptomyces rimosus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
