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Literature summary extracted from
- Expression of human cystathionine beta-synthase in Escherichia coli: purification and characterization (1994), Protein Expr. Purif., 5, 442-448.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.1.22 | expression in Escherichia coli | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.22 | 1.1 | - |
homocysteine | absence of S-adenosyl-L-methionine | Homo sapiens |  |
| 4.2.1.22 | 3.1 | - |
L-Ser | absence of S-adenosyl-L-methionine | Homo sapiens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.22 | additional information | - |
high tendency for aggregation | Homo sapiens |
| 4.2.1.22 | 63000 | - |
x * 63000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.22 | L-Serine + homocysteine | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.22 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.1.22 | - |
Homo sapiens |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.22 | 3.5 | - |
- |
Homo sapiens |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 4.2.1.22 | -70°C | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.22 | L-Serine + homocysteine | ir | Homo sapiens | Cystathionine + H2O | - |
? | |
| 4.2.1.22 | L-Serine + homocysteine | - |
Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.1.22 | ? | x * 63000, SDS-PAGE | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.22 | pyridoxal 5'-phosphate | requirement | Homo sapiens | |
| 4.2.1.22 | S-adenosyl-L-methionine | allosterical regulation, increase of the enzyme's affinity for homocysteine | Homo sapiens | |
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