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Literature summary extracted from

  • Walker, J.; Barrett, J.
    Biochemical characterization of the enzyme responsible for activated L-serine sulphydrase" activity in nematodes (1992), Exp. Parasitol., 74, 205-215.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.22 2,4-Dichlorophenol
-
 Haemonchus contortus
4.2.1.22 2,4-Dichlorophenol
-
 Nippostrongylus brasiliensis
4.2.1.22 alizarin
-
 Haemonchus contortus
4.2.1.22 alizarin
-
 Nippostrongylus brasiliensis
4.2.1.22 aminooxyacetic acid
-
 Haemonchus contortus
4.2.1.22 aminooxyacetic acid
-
 Nippostrongylus brasiliensis
4.2.1.22 bithionol
-
 Haemonchus contortus
4.2.1.22 bithionol
-
 Nippostrongylus brasiliensis
4.2.1.22 closantel
-
 Haemonchus contortus
4.2.1.22 closantel
-
 Nippostrongylus brasiliensis
4.2.1.22 Dichlorophene
-
 Haemonchus contortus
4.2.1.22 Dichlorophene
-
 Nippostrongylus brasiliensis
4.2.1.22 ellagic acid
-
 Haemonchus contortus
4.2.1.22 ellagic acid
-
 Nippostrongylus brasiliensis
4.2.1.22 Hexachlorophene
-
 Haemonchus contortus
4.2.1.22 Hexachlorophene
-
 Nippostrongylus brasiliensis
4.2.1.22 purpurogallin
-
 Haemonchus contortus
4.2.1.22 purpurogallin
-
 Nippostrongylus brasiliensis
4.2.1.22 quercetin
-
 Haemonchus contortus
4.2.1.22 quercetin
-
 Nippostrongylus brasiliensis
4.2.1.22 Rafoxanide
-
 Haemonchus contortus
4.2.1.22 Rafoxanide
-
 Nippostrongylus brasiliensis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.22 0.21
-
 L-Cys
-
 Haemonchus contortus
4.2.1.22 5.58
-
 2-mercaptoethanol
-
 Haemonchus contortus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.22 cytosol
-
 Haemonchus contortus 5829
-
4.2.1.22 cytosol
-
 Nippostrongylus brasiliensis 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.22 L-Serine + homocysteine Haemonchus contortus
-
 ?
-
 ?
4.2.1.22 L-Serine + homocysteine Nippostrongylus brasiliensis
-
 ?
-
 ?
4.2.1.22 L-Serine + homocysteine Trichostrongylus colubriformis
-
 ?
-
 ?
4.2.1.22 L-Serine + homocysteine Steinernema bibionis
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Haemonchus contortus
-
-
-
4.2.1.22 Nippostrongylus brasiliensis
-
-
-
4.2.1.22 Steinernema bibionis
-
-
-
4.2.1.22 Trichostrongylus colubriformis
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.2.1.22 L-serine + L-homocysteine = L-cystathionine + H2O sequential bisubstrate mechanism in which no product release occurs until both substrates are bound to the enzyme to form a ternary complex Trichostrongylus colubriformis
a
4.2.1.22 L-serine + L-homocysteine = L-cystathionine + H2O sequential bisubstrate mechanism in which no product release occurs until both substrates are bound to the enzyme to form a ternary complex Steinernema bibionis
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 L-Cysteine + 1-butanethiol
-
 Haemonchus contortus ?
-
 ?
4.2.1.22 L-Cysteine + 1-butanethiol
-
 Nippostrongylus brasiliensis ?
-
 ?
4.2.1.22 L-Cysteine + 1-mercapto-2-propanol
-
 Haemonchus contortus HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
-
 ?
4.2.1.22 L-Cysteine + 1-mercapto-2-propanol
-
 Nippostrongylus brasiliensis HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
-
 ?
4.2.1.22 L-Cysteine + 1-mercapto-2-propanol
-
 Trichostrongylus colubriformis HOOC-CH(NH2)-CH2-S-CH2-CH(OH)-CH3 + H2S
-
 ?
4.2.1.22 L-Cysteine + 1-pentanethiol
-
 Haemonchus contortus ?
-
 ?
4.2.1.22 L-Cysteine + 1-pentanethiol
-
 Nippostrongylus brasiliensis ?
-
 ?
4.2.1.22 L-Cysteine + 2-mercaptoethanol
-
 Trichostrongylus colubriformis HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
-
 ?
4.2.1.22 L-Cysteine + 2-mercaptoethanol
-
 Steinernema bibionis HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
-
 ?
4.2.1.22 L-cysteine + 2-mercaptoethanol
-
 Haemonchus contortus S-hydroxyethyl-L-cysteine + H2S
-
 ?
4.2.1.22 L-Cysteine + cysteamine
-
 Haemonchus contortus ?
-
 ?
4.2.1.22 L-Cysteine + cysteamine
-
 Nippostrongylus brasiliensis ?
-
 ?
4.2.1.22 L-Cysteine + dithioerythritol
-
 Haemonchus contortus ?
-
 ?
4.2.1.22 L-Cysteine + dithioerythritol
-
 Nippostrongylus brasiliensis ?
-
 ?
4.2.1.22 L-Cysteine + dithiothreitol
-
 Haemonchus contortus ?
-
 ?
4.2.1.22 L-Cysteine + dithiothreitol
-
 Nippostrongylus brasiliensis ?
-
 ?
4.2.1.22 L-Cysteine + DL-homocysteine
-
 Haemonchus contortus Cystathionine + H2S
-
 ?
4.2.1.22 L-Cysteine + DL-homocysteine
-
 Nippostrongylus brasiliensis Cystathionine + H2S
-
 ?
4.2.1.22 L-Cysteine + DL-homocysteine
-
 Trichostrongylus colubriformis Cystathionine + H2S
-
 ?
4.2.1.22 L-Cysteine + monothioglycerol
-
 Haemonchus contortus ?
-
 ?
4.2.1.22 L-Cysteine + monothioglycerol
-
 Nippostrongylus brasiliensis ?
-
 ?
4.2.1.22 L-Cysteine + monothioglycerol
-
 Trichostrongylus colubriformis ?
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Haemonchus contortus Cystathionine + H2O
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Nippostrongylus brasiliensis Cystathionine + H2O
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Trichostrongylus colubriformis Cystathionine + H2O
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Steinernema bibionis Cystathionine + H2O
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Haemonchus contortus ?
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Nippostrongylus brasiliensis ?
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Trichostrongylus colubriformis ?
-
 ?
4.2.1.22 L-Serine + homocysteine
-
 Steinernema bibionis ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.22 9
-
-
 Haemonchus contortus
4.2.1.22 9
-
-
 Nippostrongylus brasiliensis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.2.1.22 4.5 10.5
-
 Nippostrongylus brasiliensis
4.2.1.22 6.5 10.5
-
 Haemonchus contortus

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.22 pyridoxal 5'-phosphate requirement Haemonchus contortus
4.2.1.22 pyridoxal 5'-phosphate requirement Nippostrongylus brasiliensis