Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Porter, P.N.; Grishaver, M.S.; Jones, O.W.
    Characterization of human cystathionine beta-synthase. Evidence for the identity of human L-serine dehydratase and cystathionine beta-synthase (1974), Biochim. Biophys. Acta, 364, 128-139.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.22 hydroxylamine
-
Homo sapiens
4.3.1.17 hydroxylamine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.22 L-Serine + homocysteine Homo sapiens
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Homo sapiens
-
-
-
4.3.1.17 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.22
-
Homo sapiens
4.3.1.17
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.22 liver
-
Homo sapiens
-
4.3.1.17 liver fetal Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3.1.17 additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 L-Serine + homocysteine
-
Homo sapiens Cystathionine + H2O
-
?
4.2.1.22 L-Serine + homocysteine
-
Homo sapiens ?
-
?
4.2.1.22 L-Serine + HS-
-
Homo sapiens Cysteine + OH-
-
?
4.3.1.17 L-serine
-
Homo sapiens pyruvate + NH3
-
?

Synonyms

EC Number Synonyms Comment Organism
4.3.1.17 More L-serine dehydratase and cystathionine beta-synthase are the same enzyme Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.3.1.17 45
-
10 min, stable up to Homo sapiens
4.3.1.17 50
-
10 min, about 10% loss of activity Homo sapiens
4.3.1.17 55
-
10 min, about 50% loss of activity Homo sapiens
4.3.1.17 60
-
10 min, about 75% loss of activity Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.22 pyridoxal 5'-phosphate requirement Homo sapiens