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Literature summary extracted from

  • Roper, M.D.; Kraus, J.P.
    Rat cystathionine beta-synthase: expression of four alternatively spliced isoforms in transfected cultured cells (1992), Arch. Biochem. Biophys., 298, 514-521.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.22 expression in CHO/duk- cell line Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.22 6
-
L-Ser value is reduced 8fold by S-adenosyl-L-methionine Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.22 L-Serine + homocysteine Rattus norvegicus initial step in transsulfuration forming cysteine. Homocysteine is a relatively toxic amino acid, which levels have to be kept low ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.22 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 L-Serine + homocysteine
-
Rattus norvegicus Cystathionine + H2O
-
?
4.2.1.22 L-Serine + homocysteine initial step in transsulfuration forming cysteine. Homocysteine is a relatively toxic amino acid, which levels have to be kept low Rattus norvegicus ?
-
?