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Literature summary extracted from
- Cystathionine beta-synthase from human liver: improved purification scheme and additional characterization of the enzyme in crude and pure form (1983), Arch. Biochem. Biophys., 222, 44-52.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.22 | 0.59 | - |
homocysteine | - |
Homo sapiens |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.22 | 48000 | - |
2 * 48000, proteolytically activated enzyme, derived from 4 * 68000 enzyme, SDS-PAGE | Homo sapiens |
| 4.2.1.22 | 68000 | - |
2 * 48000, proteolytically activated enzyme, derived from 4 * 68000 enzyme, SDS-PAGE | Homo sapiens |
| 4.2.1.22 | 68000 | - |
4 * 68000, enzyme from fresh liver extract, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.22 | L-Serine + homocysteine | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.22 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.1.22 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.2.1.22 | liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.22 | 5.6 | - |
- |
Homo sapiens |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 4.2.1.22 | -80°C, potassium phosphate buffer, pH 6.5, 1 mM 2-mercaptoethanol, 3 years, no loss of activity | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.22 | L-Serine + homocysteine | - |
Homo sapiens | Cystathionine + H2O | - |
? | |
| 4.2.1.22 | L-Serine + homocysteine | - |
Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.1.22 | dimer | 2 * 48000, proteolytically activated enzyme, derived from 4 * 68000 enzyme, SDS-PAGE | Homo sapiens |
| 4.2.1.22 | tetramer | 4 * 68000, enzyme from fresh liver extract, SDS-PAGE | Homo sapiens |
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