EC Number | General Stability | Organism |
---|---|---|
4.2.1.22 | 2-mercaptoethanol stabilizes | Homo sapiens |
4.2.1.22 | 2-mercaptoethanol stabilizes | Rattus norvegicus |
4.2.1.22 | high protein concentration stabilizes | Homo sapiens |
4.2.1.22 | high protein concentration stabilizes | Rattus norvegicus |
4.2.1.22 | lyophilization inactivates | Homo sapiens |
4.2.1.22 | lyophilization inactivates | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.22 | aminooxyacetic acid | - |
Homo sapiens | |
4.2.1.22 | aminooxyacetic acid | - |
Rattus norvegicus | |
4.2.1.22 | hydroxylamine | - |
Homo sapiens | |
4.2.1.22 | hydroxylamine | - |
Rattus norvegicus | |
4.4.1.1 | cycloserine | partially competitive | Rattus norvegicus | |
4.4.1.1 | Cys | - |
Rattus norvegicus | |
4.4.1.1 | cysteamine | - |
Rattus norvegicus | |
4.4.1.1 | Penicillamine | - |
Rattus norvegicus | |
4.4.1.10 | L-Ser | - |
Gallus gallus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.22 | 0.59 | - |
homocysteine | - |
Homo sapiens | |
4.2.1.22 | 1.15 | - |
L-Ser | - |
Homo sapiens | |
4.2.1.22 | 8 | - |
L-Ser | - |
Rattus norvegicus | |
4.2.1.22 | 18 | - |
homocysteine | - |
Rattus norvegicus | |
4.2.1.22 | 24 | - |
2-mercaptoethanol | - |
Rattus norvegicus | |
4.2.1.22 | 36 | - |
L-Cys | cosubstrate 2-mercaptoethanol | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
4.4.1.1 | 45000 | - |
4 * 45000, SDS-PAGE | Rattus norvegicus |
4.4.1.1 | 160000 | - |
- |
Rattus norvegicus |
4.4.1.10 | 120000 | - |
- |
Gallus gallus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.22 | L-Serine + homocysteine | Gallus gallus | - |
? | - |
? | |
4.2.1.22 | L-Serine + homocysteine | Homo sapiens | - |
? | - |
? | |
4.2.1.22 | L-Serine + homocysteine | Rattus norvegicus | - |
? | - |
? | |
4.4.1.10 | L-Cys + sulfite | Gallus gallus | production of L-cysteate, the precursor of the fetal metabolite taurine | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.22 | Gallus gallus | - |
- |
- |
4.2.1.22 | Homo sapiens | - |
- |
- |
4.2.1.22 | Rattus norvegicus | - |
- |
- |
4.4.1.1 | Rattus norvegicus | - |
- |
- |
4.4.1.10 | Gallus gallus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.4.1.1 | - |
Rattus norvegicus |
4.4.1.10 | - |
Gallus gallus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
4.4.1.10 | L-cysteine + sulfite = L-cysteate + hydrogen sulfide | beta-replacement reaction | Gallus gallus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.2.1.22 | liver | - |
Gallus gallus | - |
4.2.1.22 | liver | - |
Homo sapiens | - |
4.2.1.22 | liver | - |
Rattus norvegicus | - |
4.4.1.1 | liver | - |
Rattus norvegicus | - |
4.4.1.10 | embryo | yolk-sac | Gallus gallus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
4.4.1.1 | 10 | - |
- |
Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
4.4.1.1 | -50°C, potassium phosphate buffer, pH 7.5, enzyme stabilized by pyridoxal 5'-phosphate, EDTA, and dithiothreitol retains full activity for several months | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.22 | L-Cysteine + 2-mercaptoethanol | - |
Rattus norvegicus | HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S | - |
? | |
4.2.1.22 | L-Serine + homocysteine | - |
Gallus gallus | Cystathionine + H2O | - |
? | |
4.2.1.22 | L-Serine + homocysteine | - |
Homo sapiens | Cystathionine + H2O | - |
? | |
4.2.1.22 | L-Serine + homocysteine | - |
Rattus norvegicus | Cystathionine + H2O | - |
? | |
4.2.1.22 | L-Serine + homocysteine | - |
Gallus gallus | ? | - |
? | |
4.2.1.22 | L-Serine + homocysteine | - |
Homo sapiens | ? | - |
? | |
4.2.1.22 | L-Serine + homocysteine | - |
Rattus norvegicus | ? | - |
? | |
4.4.1.1 | alpha,beta-diaminopropionate | beta,gamma-elimination | Rattus norvegicus | ? | - |
? | |
4.4.1.1 | djenkolic acid | beta,gamma-elimination | Rattus norvegicus | ? | - |
? | |
4.4.1.1 | homocysteine | beta,gamma-elimination | Rattus norvegicus | ? | - |
? | |
4.4.1.1 | L-Cys | alpha,beta-elimination | Rattus norvegicus | H2S + NH3 + pyruvate | - |
? | |
4.4.1.1 | L-cystathionine + H2O | beta,gamma-elimination | Rattus norvegicus | ? | - |
? | |
4.4.1.1 | L-cystine | alpha,beta-elimination | Rattus norvegicus | ? | - |
? | |
4.4.1.1 | L-homoserine | beta,gamma-elimination | Rattus norvegicus | ? | - |
? | |
4.4.1.1 | Lanthionine | beta,gamma-elimination | Rattus norvegicus | ? | - |
? | |
4.4.1.10 | L-Cys + 2-mercaptoethanol | - |
Gallus gallus | S-(2-hydroxyethyl)cysteine + ? | - |
? | |
4.4.1.10 | L-Cys + 3-mercaptopropionate | weak | Gallus gallus | ? | - |
? | |
4.4.1.10 | L-Cys + dithiothreitol | - |
Gallus gallus | ? | - |
? | |
4.4.1.10 | L-Cys + sulfite | - |
Gallus gallus | L-cysteate + H2S | - |
? | |
4.4.1.10 | L-Cys + sulfite | production of L-cysteate, the precursor of the fetal metabolite taurine | Gallus gallus | ? | - |
? | |
4.4.1.10 | L-Cys + thioglycolate | weak | Gallus gallus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
4.4.1.1 | tetramer | 4 * 45000, SDS-PAGE | Rattus norvegicus |
4.4.1.10 | dimer | - |
Gallus gallus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.2.1.22 | 8.4 | 9 | - |
Homo sapiens |
4.4.1.10 | 8.7 | 8.8 | - |
Gallus gallus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.22 | pyridoxal 5'-phosphate | requirement | Homo sapiens | |
4.2.1.22 | pyridoxal 5'-phosphate | requirement | Rattus norvegicus | |
4.4.1.1 | pyridoxal 5'-phosphate | contains 4 mol of pyridoxal 5'-phosphate per mol of enzyme | Rattus norvegicus | |
4.4.1.10 | pyridoxal 5'-phosphate | dependent | Gallus gallus |