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Literature summary extracted from
- Inhibition of steroid C17(20) lyase with C-17-heteroaryl steroids (1996), Bioorg. Med. Chem., 4, 1411-1420.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.14.14.32 | medicine | inhibition of EC 4.1.2.30 is a potential therapeutic approach for the treatment of both breast and prostrate cancers | Macaca fascicularis |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.32 | additional information | overview | Macaca fascicularis |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.32 | Macaca fascicularis | - |
cynomolgus monkey | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.32 | testis | - |
Macaca fascicularis | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.32 | 17alpha-Hydroxypregnenolone | - |
Macaca fascicularis | Dehydroepiandrosterone + acetaldehyde | DHEA | ? |  |
| 1.14.14.32 | 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Macaca fascicularis | androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
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Release 2023.1 (January 2023)
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