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Literature summary extracted from

  • Mathis, J.B.; Brown, G.M.
    The biosynthesis of folic acid. XI. Purification and properties of dihydroneopterin aldolase (1970), J. Biol. Chem., 245, 3015-3025.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.2.25 EDTA increases activity Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.2.25 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine competitive Escherichia coli
4.1.2.25 dihydrofolic acid
-
Escherichia coli
4.1.2.25 Dihydropteroic acid slight Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.2.25 0.009
-
2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.25 Escherichia coli
-
-
-
4.1.2.25 Escherichia coli B / ATCC 11303
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.2.25
-
Escherichia coli

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.2.25 0.0039
-
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.25 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde
-
?
4.1.2.25 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
Escherichia coli B / ATCC 11303 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde
-
?
4.1.2.25 2-amino-4-hydroxy-6-(L-threo-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
Escherichia coli ?
-
?
4.1.2.25 2-amino-4-hydroxy-6-(L-threo-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
Escherichia coli B / ATCC 11303 ?
-
?
4.1.2.25 additional information no activity with: 2-amino-4-hydroxy-6-(D-threo-1,2,3-trihydroxypropyl)-7,8-dihydropteridine and 2-amino-4-hydroxy-6-(L-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine Escherichia coli ?
-
?
4.1.2.25 additional information no activity with: 2-amino-4-hydroxy-6-(D-threo-1,2,3-trihydroxypropyl)-7,8-dihydropteridine and 2-amino-4-hydroxy-6-(L-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine Escherichia coli B / ATCC 11303 ?
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.1.2.25 100
-
5 min, stable Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.2.25 9.6
-
-
Escherichia coli