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Literature summary extracted from

  • Llamazares, S.; Moreira, A.; Tavares, A.; et al.
    Polo encodes a protein kinase homolog required for mitosis in Drosophila (1991), Genes Dev., 5, 2153-2165.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.21
-
 Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.21 chromosome polo kinase undergoes cell cycle-dependent changes in its distribution. It is predominantly cytoplasmic during interphase, it becomes associated with condensed chromosomes toward the end of prophase, and it remains associated with chromosomes until telophase, whereupon it becomes cytoplasmic Drosophila melanogaster 5694
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2.7.11.21 cytoplasm polo kinase undergoes cell cycle-dependent changes in its distribution. It is predominantly cytoplasmic during interphase, it becomes associated with condensed chromosomes toward the end of prophase, and it remains associated with chromosomes until telophase, whereupon it becomes cytoplasmic Drosophila melanogaster 5737
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.21 additional information Drosophila melanogaster normal bipolar spindles with polyploid complements of chromosomes, bipolar spindles in which one pole can be unusually broad, and monopolar spindles ?
-
 ?
2.7.11.21 additional information Drosophila melanogaster mutation in polo leads to a variety of abnormal mitoses in Drosophila larval neuroblasts. These include otherwise normal looking mitotic spindles upon which chromosomes appear overcondensed ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.21 Drosophila melanogaster P52304
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.21 larva
-
 Drosophila melanogaster
-
2.7.11.21 neuroblast
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.21 additional information normal bipolar spindles with polyploid complements of chromosomes, bipolar spindles in which one pole can be unusually broad, and monopolar spindles Drosophila melanogaster ?
-
 ?
2.7.11.21 additional information mutation in polo leads to a variety of abnormal mitoses in Drosophila larval neuroblasts. These include otherwise normal looking mitotic spindles upon which chromosomes appear overcondensed Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.21 protein kinase polo
-
 Drosophila melanogaster