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Literature summary extracted from

  • Premont, R.T.; Koch, W.J.; Inglese, J.; Lefkowitz, R.J.
    Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases (1994), J. Biol. Chem., 269, 6832-6841.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.16 membrane GRK5 protein does not undergo agonist-dependent translocation from cytosol to membranes as do beta-adrenergic receptor kinase and rhodopsin kinase, but rather appears to associate with membranes constitutively Bos taurus 16020
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Organism

EC Number Organism UniProt Comment Textmining
2.7.11.16 Bos taurus P43249
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-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.16 phosphoprotein major autophosphorylation sites are Ser484 and Thr485 Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.16
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.16 brain very weak activity Bos taurus
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2.7.11.16 heart high activity Bos taurus
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2.7.11.16 kidney very weak activity Bos taurus
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2.7.11.16 liver very weak activity Bos taurus
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2.7.11.16 lung high activity Bos taurus
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2.7.11.16 additional information most abundantly in lung, heart, retina, and lingual epithelium, but expressed very little in brain, liver, kidney, or testis Bos taurus
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2.7.11.16 retina high activity Bos taurus
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2.7.11.16 testis very weak activity Bos taurus
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2.7.11.16 tongue epithelium
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 Bos taurus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.16 ATP + beta 2-adrenergic receptor phosphorylation in an agonist-dependent manner, phosphorylates the C-terminal tail regions of both receptor proteins Bos taurus ADP + phosphorylated beta 2-adrenergic receptor
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 ?
2.7.11.16 ATP + protein major autophosphorylation sites are Ser484 and Thr485 Bos taurus ADP + phosphoprotein
-
 ?
2.7.11.16 ATP + rhodopsin GRK5 phosphorylates rhodopsin in a light-dependent manner, phosphorylates the C-terminal tail region Bos taurus ADP + phosphorylated rhodopsin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.16 G protein-coupled receptor kinase GRK5
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 Bos taurus
2.7.11.16 GRK5
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 Bos taurus