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Literature summary extracted from

  • Parruti, G.; Ambrosini, G.; Sallese, M.; De Blasi, A.
    Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2 (1993), Biochem. Biophys. Res. Commun., 190, 475-481.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.15 cDNA encoding beta-ARK 2 is cloned, expressed in COS-7 cells and sequenced Homo sapiens
2.7.11.15 expression in COS7 cells Homo sapiens
2.7.11.15 very similar cDNA sequences of bovine and human kinases Bos taurus
2.7.11.15 very similar sequences of bovine and human kinases Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.15 heparin
-
Bos taurus
2.7.11.15 heparin
-
Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.15 Mg2+ requirement Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.15 additional information
-
amino acid sequences of human and bovine beta-ARK 1 and 2 Bos taurus
2.7.11.15 additional information
-
amino acid sequences of human and bovine beta-ARK 1 and 2 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor Bos taurus agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor Homo sapiens agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor Homo sapiens functional role of the beta-ARK/beta-arrestin mechanism of receptor desensitization in immune cells ADP + phospho-beta-adrenergic receptor
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Bos taurus
-
enzyme exists in 2 subtypes: beta-ARK 1 and beta-ARK 2
-
2.7.11.15 Homo sapiens P35626
-
-
2.7.11.15 Homo sapiens P35626 beta-ARK 2, enzyme exists in 2 subtypes: beta-ARK1 and 2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 brain
-
Bos taurus
-
2.7.11.15 cerebellum
-
Bos taurus
-
2.7.11.15 heart moderate expression of beta-ARK 2 Homo sapiens
-
2.7.11.15 IMR-32 cell beta-ARK 2 Homo sapiens
-
2.7.11.15 leukocyte peripheral blood leukocytes Homo sapiens
-
2.7.11.15 leukocyte mononuclear, peripheral blood leukocytes, high expression Homo sapiens
-
2.7.11.15 leukocyte beta-ARK 2 Bos taurus
-
2.7.11.15 leukocyte beta-ARK 2 Homo sapiens
-
2.7.11.15 lung moderate expression of beta-ARK 2 Homo sapiens
-
2.7.11.15 additional information tissue distribution of beta-ARK 2 Bos taurus
-
2.7.11.15 additional information tissue distribution of beta-ARK 2 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Homo sapiens ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor agonist-occupied form of the receptor Homo sapiens ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + beta-adrenergic receptor functional role of the beta-ARK/beta-arrestin mechanism of receptor desensitization in immune cells Homo sapiens ADP + phospho-beta-adrenergic receptor
-
?
2.7.11.15 ATP + rhodopsin in form of bovine rod outer segments Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.15 ATP + rhodopsin in form of bovine rod outer segments Homo sapiens ADP + phosphorhodopsin
-
?
2.7.11.15 ATP + rhodopsin recombinant beta-ARK 2: 40% of efficiency of beta-ARK 1 in phosphorylating rhodopsin Homo sapiens ADP + phosphorhodopsin
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 beta-adrenergic receptor kinase 2
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
Bos taurus
2.7.11.15 ATP
-
Homo sapiens