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Literature summary extracted from

  • Hibasami, H.; Borchardt, R.T.; Chen, S.Y.; Coward, J.K.; Pegg, A.E.
    Studies of inhibition of rat spermidine synthase and spermine synthase (1980), Biochem. J., 187, 419-428.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.16 5'-ethylthioadenosine
-
 Rattus norvegicus
2.5.1.16 5'-methylthioadenosine
-
 Rattus norvegicus
2.5.1.16 5'-methylthiotubercidin
-
 Rattus norvegicus
2.5.1.16 additional information S-adenosyl-L-homocysteine Rattus norvegicus
2.5.1.16 S-Adenosyl-4-methylthiobutyric acid
-
 Rattus norvegicus
2.5.1.16 S-adenosyl-L-ethionine
-
 Rattus norvegicus
2.5.1.16 S-Adenosyl-L-homocysteine sulfone
-
 Rattus norvegicus
2.5.1.16 S-adenosyl-L-methionine
-
 Rattus norvegicus
2.5.1.16 S-Tubercidinylmethionine
-
 Rattus norvegicus
2.5.1.16 Substrate and product analogues overview Rattus norvegicus
2.5.1.16 Sulfoxide and sulfone derivatives of decarboxylated S-adenosyl-L-homocysteine
-
 Rattus norvegicus
2.5.1.22 5'-ethylthioadenosine strong Rattus norvegicus
2.5.1.22 5'-methylthioadenosine strong Rattus norvegicus
2.5.1.22 5'-methylthiotubercidin strong, in vivo and in vitro, kinetics Rattus norvegicus
2.5.1.22 S-Adenosyl-4-methylthiobutyrate 70-98% inhibition at 1 mm Rattus norvegicus
2.5.1.22 S-adenosyl-D-methionine 70-98% inhibition at 1 mm Rattus norvegicus
2.5.1.22 S-adenosyl-L-ethionine 70-98% inhibition at 1 mm Rattus norvegicus
2.5.1.22 S-adenosyl-L-homocysteine weak Rattus norvegicus
2.5.1.22 S-adenosyl-L-methionine prostate Rattus norvegicus
2.5.1.22 S-Tubercidinylmethionine 70-98% inhibition at 1 mm Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Rattus norvegicus
-
 5'-methylthioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.16 Rattus norvegicus
-
 male Sprague Dawley strain
-
2.5.1.16 Rattus norvegicus Sprague Dawley
-
 male Sprague Dawley strain
-
2.5.1.22 Rattus norvegicus
-
 Sprague-Dawley
-
2.5.1.22 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.16 prostate gland
-
 Rattus norvegicus
-
2.5.1.22 prostate gland
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.16 0.055
-
-
 Rattus norvegicus
2.5.1.22 0.0062
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-thiopropylamine sulfone + 1,4-diaminobutane
-
 Rattus norvegicus ?
-
 ?
2.5.1.16 S-adenosyl-3-thiopropylamine sulfoxide + 1,4-diaminobutane
-
 Rattus norvegicus ?
-
 ?
2.5.1.16 S-adenosyl-3-thiopropylamine sulfoxide + 1,4-diaminobutane
-
 Rattus norvegicus Sprague-Dawley ?
-
 ?
2.5.1.16 S-adenosyl-3-thiopropylamine sulfoxide + 1,4-diaminobutane
-
 Rattus norvegicus Sprague Dawley ?
-
 ?
2.5.1.16 S-adenosyl-L-ethionine + 1,4-diaminobutane
-
 Rattus norvegicus ?
-
 ?
2.5.1.16 S-adenosyl-L-ethionine + 1,4-diaminobutane
-
 Rattus norvegicus Sprague-Dawley ?
-
 ?
2.5.1.16 S-adenosyl-L-ethionine + 1,4-diaminobutane
-
 Rattus norvegicus Sprague Dawley ?
-
 ?
2.5.1.16 S-adenosyl-L-homocysteine sulfone + 1,4-diaminobutane
-
 Rattus norvegicus ?
-
 ?
2.5.1.16 S-adenosyl-L-homocysteine sulfone + 1,4-diaminobutane
-
 Rattus norvegicus Sprague-Dawley ?
-
 ?
2.5.1.16 S-adenosyl-L-homocysteine sulfone + 1,4-diaminobutane
-
 Rattus norvegicus Sprague Dawley ?
-
 ?
2.5.1.16 S-adenosyl-L-methionine + 1,4-diaminobutane
-
 Rattus norvegicus ?
-
 ?
2.5.1.16 S-adenosyl-L-methionine + 1,4-diaminobutane
-
 Rattus norvegicus Sprague-Dawley ?
-
 ?
2.5.1.16 S-adenosyl-L-methionine + 1,4-diaminobutane
-
 Rattus norvegicus Sprague Dawley ?
-
 ?
2.5.1.22 S-adenosylmethioninamine + spermidine
-
 Rattus norvegicus 5'-methylthioadenosine + spermine
-
 ?
2.5.1.22 S-adenosylmethioninamine + spermidine
-
 Rattus norvegicus Sprague-Dawley 5'-methylthioadenosine + spermine
-
 ?
2.5.1.22 S-adenosylmethioninamine + spermidine
-
 Rattus norvegicus Sprague Dawley 5'-methylthioadenosine + spermine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.16 37
-
 assay at Rattus norvegicus
2.5.1.22 37
-
-
 Rattus norvegicus