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Literature summary extracted from

  • Baillon, J.G.; Mamont, P.S.; Wagner, J.; Gerhart, F.; Lux, P.
    Fluorinated analogues of spermidine as substrates of spermine synthase (1988), Eur. J. Biochem., 176, 237-242.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.22 7,7-Difluorospermidine pH-dependent, substrate inhibition Bos taurus
2.5.1.22 7,7-Difluorospermidine pH-dependent, substrate inhibition Rattus norvegicus
2.5.1.22 7-Monofluorospermidine pH-dependent, substrate inhibition Bos taurus
2.5.1.22 7-Monofluorospermidine pH-dependent, substrate inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.22 0.00054
-
 7,7-Difluorospermidine
-
 Rattus norvegicus
2.5.1.22 0.0011
-
 7-Monofluorospermidine
-
 Rattus norvegicus
2.5.1.22 0.084 0.088 spermidine
-
 Rattus norvegicus
2.5.1.22 0.084 0.088 spermidine
-
 Bos taurus
2.5.1.22 0.093
-
 6-monofluorospermidine
-
 Rattus norvegicus
2.5.1.22 0.458
-
 6,6-difluorospermidine
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.22 Bos taurus
-
-
-
2.5.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.22 hepatoma cell
-
 Rattus norvegicus
-
2.5.1.22 spleen
-
 Rattus norvegicus
-
2.5.1.22 spleen
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.22 0.403
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.22 S-adenosylmethioninamine + 6,6-difluorospermidine
-
 Rattus norvegicus 5'-methylthioadenosine + 6,6-difluorospermine
-
 ?
2.5.1.22 S-adenosylmethioninamine + 6-monofluorospermidine
-
 Rattus norvegicus 5'-methylthioadenosine + 6-monofluorospermine
-
 ?
2.5.1.22 S-adenosylmethioninamine + 7,7-difluorospermidine
-
 Rattus norvegicus 5'-methylthioadenosine + 7,7-difluorospermine
-
 ?
2.5.1.22 S-adenosylmethioninamine + 7-monofluorospermidine
-
 Rattus norvegicus 5'-methylthioadenosine + 7-monofluorospermine
-
 ?
2.5.1.22 S-adenosylmethioninamine + spermidine mono and geminal difluorinated analogues of spermidine Rattus norvegicus 5'-methylthioadenosine + spermine
-
 ?
2.5.1.22 S-adenosylmethioninamine + spermidine mono and geminal difluorinated analogues of spermidine Bos taurus 5'-methylthioadenosine + spermine
-
 ?