Literature summary extracted from

Pegg, A.E.
Inhibition of aminopropyltransferases (1983), Methods Enzymol., 94, 294-297.

Inhibitors

EC Number	Inhibitors	Comment	Organism
2.5.1.16	5'-ethylthioadenosine	strong	Rattus norvegicus
2.5.1.16	5'-methylthioadenosine	strong	Rattus norvegicus
2.5.1.16	5'-methylthiotubercidin	in vivo and in vitro, strong	Rattus norvegicus
2.5.1.16	alpha,omega-Diamines	with 3 carbon atoms, at 0.25 mM, not at 2.5 mM substrate concentration	Rattus norvegicus
2.5.1.16	cadaverine	-	Rattus norvegicus
2.5.1.16	Cyclohexylamine	-	Rattus norvegicus
2.5.1.16	additional information	polyamines	Rattus norvegicus
2.5.1.16	S-5'-Deoxyadenosyl(5')-2-methylthioethylamine	prostate	Rattus norvegicus
2.5.1.16	S-Adenosyl-1,8-diamino-3-methylthiooctane	less efficient than the thioether	Rattus norvegicus
2.5.1.16	S-Adenosyl-1,8-diamino-3-thiooctane	prostate	Rattus norvegicus
2.5.1.16	S-Adenosyl-3-thiopropylamine sulfone	-	Rattus norvegicus
2.5.1.16	S-Adenosyl-4-methylthiobutyric acid	-	Rattus norvegicus
2.5.1.16	S-Adenosyl-L-homocysteine sulfone	-	Rattus norvegicus
2.5.1.22	1,3-diaminopropane	-	Rattus norvegicus
2.5.1.22	1,8-diaminooctane	-	Rattus norvegicus
2.5.1.22	1,9-diamino-4-azanonane	weak	Rattus norvegicus
2.5.1.22	1,9-Diamino-5-azanonane	weak	Rattus norvegicus
2.5.1.22	3,3'-Diaminodipropylamine	weak	Rattus norvegicus
2.5.1.22	5'-ethylthioadenosine	-	Rattus norvegicus
2.5.1.22	5'-methylthioadenosine	strong	Bos taurus
2.5.1.22	5'-methylthioadenosine	strong	Rattus norvegicus
2.5.1.22	5'-methylthiotubercidin	strong, in vivo and in vitro, kinetics	Rattus norvegicus
2.5.1.22	5-[5'-deoxy-5'-(C)-4',5'-didehydroadenosyl]-L-ornithine	i.e. compound A9154C, prostate	Rattus norvegicus
2.5.1.22	additional information	-	Bos taurus
2.5.1.22	additional information	not inhibitory: cyclohexylamine or dicyclohexylamine; overview on inhibitors	Rattus norvegicus
2.5.1.22	putrescine	-	Bos taurus
2.5.1.22	putrescine	-	Rattus norvegicus
2.5.1.22	S-5'-Deoxyadenosyl-(5')-1-methyl-3-(methylthio)propylamine	-	Rattus norvegicus
2.5.1.22	S-Adenosyl-1,8-diamino-3-thiooctane	weak, prostate	Rattus norvegicus
2.5.1.22	S-Adenosyl-4-methylthiobutyrate	prostate	Rattus norvegicus
2.5.1.22	S-Adenosyl-4-thiobutyrate methylester	prostate	Rattus norvegicus
2.5.1.22	S-adenosyl-D-methionine	-	Rattus norvegicus
2.5.1.22	S-adenosyl-L-methionine	prostate	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.5.1.16	S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane	Rattus norvegicus	-	5'-methylthioadenosine + spermidine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.16	Rattus norvegicus	-	-	-
2.5.1.22	Bos taurus	-	-	-
2.5.1.22	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.5.1.22	brain	-	Rattus norvegicus	-
2.5.1.22	brain	-	Bos taurus	-
2.5.1.22	prostate gland	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
2.5.1.16	S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane	-	Rattus norvegicus	5'-methylthioadenosine + spermidine	-	?
2.5.1.16	S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane	-	Rattus norvegicus	5'-methylthioadenosine + spermidine	-	?
2.5.1.16	S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane	-	Rattus norvegicus	5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane	-	?