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Literature summary extracted from

  • Ericsson, J.; Appelkvist, E.L.; Thelin, A.; Chojnacki, T.; Dallner, G.
    Isoprenoid biosynthesis in rat liver peroxisomes. Characterization of cis-prenyltransferase and squalene synthetase (1992), J. Biol. Chem., 267, 18708-18714.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.21 NADPH stimulates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.21 additional information peroxisomal squalene synthase is inhibited by sonication, microsomal enzyme not Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.21 peroxisome
-
 Rattus norvegicus 5777
-

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.21 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.21 0.16
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.21 farnesyl diphosphate + farnesyl diphosphate
-
 Rattus norvegicus diphosphate + presqualene diphosphate
-
 ?
2.5.1.21 farnesyl diphosphate + NAD(P)H
-
 Rattus norvegicus squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H in presence of reducing pyridine nucleotide, preferably NADPH, squalene is formed, in absence of reducing cofactor the rate of the condensation reaction is lower and all of the product accumulates as presqualene diphosphate Rattus norvegicus squalene + NAD(P)+ + diphosphate
-
 ?