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Literature summary extracted from

  • Ortiz de Montellano, P.R.; Wei, J.S.; Vinson, W.A.; Castillo, R.; Boparai, A.S.
    Substrate selectivity of squalene synthetase (1977), Biochemistry, 16, 2680-2685.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.21 Rattus norvegicus
-
-
-
2.5.1.21 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.21 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.21 2-methylfarnesyl diphosphate + NADPH
-
 Rattus norvegicus 11-methylsqualene + NADP+ + diphosphate
-
 ?
2.5.1.21 2-methylfarnesyl diphosphate + NADPH
-
 Saccharomyces cerevisiae 11-methylsqualene + NADP+ + diphosphate
-
 ?
2.5.1.21 3-demethylfarnesyl diphosphate + NADPH
-
 Rattus norvegicus 10-demethylsqualene + NADP+ + diphosphate
-
 ?
2.5.1.21 3-demethylfarnesyl diphosphate + NADPH
-
 Saccharomyces cerevisiae 10-demethylsqualene + NADP+ + diphosphate
-
 ?
2.5.1.21 farnesyl diphosphate + NAD(P)H
-
 Rattus norvegicus squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 farnesyl diphosphate + NAD(P)H
-
 Saccharomyces cerevisiae squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 additional information specificity overview Rattus norvegicus ?
-
 ?
2.5.1.21 additional information specificity overview Saccharomyces cerevisiae ?
-
 ?
2.5.1.21 additional information none of the following analogues gives nonpolar products: 7,11-dimethyl-3-ethyl-2,6,10-dodecatrienyl diphosphate, 6,7,10,11-tetrahydrofarnesyl diphosphate, 4-methylthiofarnesyl diphosphate, 4-fluorofarnesyl diphosphate Rattus norvegicus ?
-
 ?
2.5.1.21 additional information none of the following analogues gives nonpolar products: 7,11-dimethyl-3-ethyl-2,6,10-dodecatrienyl diphosphate, 6,7,10,11-tetrahydrofarnesyl diphosphate, 4-methylthiofarnesyl diphosphate, 4-fluorofarnesyl diphosphate Saccharomyces cerevisiae ?
-
 ?