Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Poulter, C.D.; Capson, T.L.; Thompson, M.D.; Bard, R.S.
    Squalene synthetase. Inhibition by ammonium analogues of carbocationic intermediates in the conversion of presqualene diphosphate to squalene (1989), J. Am. Chem. Soc., 111, 3734-3739.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.21 Ammonium analogues overview Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.21 Saccharomyces cerevisiae
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.5.1.21 2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+ mechanism Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.21 farnesyl diphosphate + farnesyl diphosphate
-
 Saccharomyces cerevisiae diphosphate + presqualene diphosphate
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H a single active site catalyzes both reactions Saccharomyces cerevisiae squalene + NAD(P)+ + diphosphate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.21 NADPH
-
 Saccharomyces cerevisiae