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Literature summary extracted from

  • Washburn, W.N.; Kow, R.
    Investigations of substrate specificity of squalene synthase (1977), Tetrahedron Lett., 18, 1555-1558.
No PubMed abstract available

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.21 Saccharomyces cerevisiae
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.21 (E,E)-7-desmethylfarnesyl diphosphate + NADPH at 60% of the efficiency that farnesyl diphosphate is converted to squalene Saccharomyces cerevisiae 6,19-didesmethylsqualene + NADP+ + diphosphate in absence of farnesyl diphosphate, 6-desmethylsqualene is produced in presence of farnesyl diphosphate ?
2.5.1.21 10,11-dihydrofarnesyl diphosphate + NADPH at 60% of the efficiency that farnesyl diphosphate is converted to squalene Saccharomyces cerevisiae 2,3,22,23-tetrahydrosqualene + NADP+ + diphosphate
-
 ?
2.5.1.21 farnesyl diphosphate + NAD(P)H
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 Saccharomyces cerevisiae squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 additional information specificity overview Saccharomyces cerevisiae ?
-
 ?
2.5.1.21 additional information no substrate: 6,7-dihydrofarnesyl diphosphate, 3-desmethylfarnesyl diphosphate Saccharomyces cerevisiae ?
-
 ?
2.5.1.21 additional information not metabolized: (E)-6,7,10,11-tetrahydrofarnesyl diphosphate Saccharomyces cerevisiae ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.21 37
-
 assay at Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.21 NADPH
-
 Saccharomyces cerevisiae