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Literature summary extracted from

  • Sasiak, K.; Rilling, H.C.
    Purification to homogeneity and some properties of squalene synthetase (1988), Arch. Biochem. Biophys., 260, 622-627.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.21 farnesyl diphosphate substrate inhibitor of squalene synthase reaction Saccharomyces cerevisiae
2.5.1.21 NADP+ inhibitor of squalene synthesis Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.21 0.004
-
 NADPH
-
 Saccharomyces cerevisiae
2.5.1.21 0.004
-
 NADH
-
 Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.21 47000
-
 x * 47000, SDS-PAGE Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.21 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.21
-
 Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.21 0.816
-
 presqualene Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.21 (2E,6E)-farnesyl diphosphate + NADH + H+
-
 Saccharomyces cerevisiae squalene + diphosphate + NAD+
-
 ?
2.5.1.21 farnesyl diphosphate + farnesyl diphosphate
-
 Saccharomyces cerevisiae diphosphate + presqualene diphosphate
-
 ?
2.5.1.21 farnesyl diphosphate + NAD(P)H
-
 Saccharomyces cerevisiae squalene + diphosphate + NAD(P)+ presqualene diphosphate and squalene are produced in a ratio of 6:1 ?
2.5.1.21 presqualene diphosphate + NAD(P)H one protein with 2 catalytic sites may be involved in synthesis of presqualene diphosphate and for its reduction to squalene Saccharomyces cerevisiae squalene + NAD(P)+ + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.21 ? x * 47000, SDS-PAGE Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.21 NADPH
-
 Saccharomyces cerevisiae