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Literature summary extracted from

  • Lee, H.; Iglewski, W.J.
    Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A (1984), Proc. Natl. Acad. Sci. USA, 81, 2703-2707.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.36 Cytoplasmic extract of pyBHK-cells not fragment A Mesocricetus auratus
2.4.2.36 histamine 250 mM, almost complete inhibition Mesocricetus auratus
2.4.2.36 additional information cellular ADPribosyltransferase is not inhibited by anti-fragment A-antiserum Mesocricetus auratus
2.4.2.36 additional information fragment A and toxin A are not inhibited by histamine Pseudomonas aeruginosa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.36 extracellular
-
 Bos taurus
-
-
2.4.2.36 extracellular
-
 Mesocricetus auratus
-
-
2.4.2.36 extracellular fragment A of diphtheria toxin Pseudomonas aeruginosa
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.36 NAD+ + elongation factor 2 Pseudomonas aeruginosa
-
 nicotinamide + ADPribose-elongation factor 2
-
 r
2.4.2.36 NAD+ + elongation factor 2 Bos taurus liver enzyme nicotinamide + ADPribose-elongation factor 2
-
 ?
2.4.2.36 NAD+ + elongation factor 2 Mesocricetus auratus i.e. elongation factor 2 of baby hamster kidney cells, forward ADP-ribosylation reaction is reversed by fragment A from Pseudomonas aeruginosa nicotinamide + ADPribose-elongation factor 2
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.36 Bos taurus
-
-
-
2.4.2.36 Mesocricetus auratus
-
 baby
-
2.4.2.36 Pseudomonas aeruginosa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.36 kidney polyoma virus transformed baby hamster kidney cells, i.e. pyBHK-cells Mesocricetus auratus
-
2.4.2.36 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.36 NAD+ + elongation factor 2
-
 Pseudomonas aeruginosa nicotinamide + ADPribose-elongation factor 2
-
 r
2.4.2.36 NAD+ + elongation factor 2 liver enzyme Bos taurus nicotinamide + ADPribose-elongation factor 2
-
 ?
2.4.2.36 NAD+ + elongation factor 2 i.e. elongation factor 2 of baby hamster kidney cells, forward ADP-ribosylation reaction is reversed by fragment A from Pseudomonas aeruginosa Mesocricetus auratus nicotinamide + ADPribose-elongation factor 2
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.36 22
-
 assay at Mesocricetus auratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.36 6.6
-
 assay at, nicotinamide + ADPribose-elongation factor 2 Mesocricetus auratus
2.4.2.36 8
-
 assay at, NAD+ + elongation factor 2 Mesocricetus auratus