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Literature summary extracted from

  • Kian, I.A.; Etingof, R.N.
    Purine biosynthesis de novo in bovine retina: purification and characterization of amidophosphoribosyl transferase and phosphoribosyl pyrophosphate synthetase (1999), Biochemistry, 64, 648-651.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.6.1 ADP
-
 Bos taurus
2.7.6.1 AMP
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.14 0.66
-
 5-phospho-alpha-D-ribose 1-diphosphate
-
 Bos taurus
2.4.2.14 0.75
-
 L-glutamine
-
 Bos taurus
2.7.6.1 0.038
-
 D-ribose 5-phosphate pH and temperature conditions not mentioned Bos taurus
2.7.6.1 0.053
-
 ATP pH and temperature conditions not mentioned Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.6.1 34000
-
 x * 50000 + x * 34000 + x * 39000 + x * 41000, subunit of 34000 Da is the catalytic subunit Bos taurus
2.7.6.1 39000
-
 x * 50000 + x * 34000 + x * 39000 + x * 41000, subunit of 34000 Da is the catalytic subunit Bos taurus
2.7.6.1 41000
-
 x * 50000 + x * 34000 + x * 39000 + x * 41000, subunit of 34000 Da is the catalytic subunit Bos taurus
2.7.6.1 50000
-
 x * 50000 + x * 34000 + x * 39000 + x * 41000, subunit of 34000 Da is the catalytic subunit Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.14 Bos taurus
-
-
-
2.7.6.1 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.14
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.14 retina
-
 Bos taurus
-
2.7.6.1 retina
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.14 L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
 Bos taurus 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate
-
 ?
2.7.6.1 ATP + D-ribose 5-phosphate
-
 Bos taurus AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.6.1 ? x * 50000 + x * 34000 + x * 39000 + x * 41000, subunit of 34000 Da is the catalytic subunit Bos taurus