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Literature summary extracted from

  • Shibata, K.; Taguchi, H.; Nishitani, H.; Okumura, K.; Shimabayashi, Y.; Matsushita, N.; Yamazaki, H.
    End product inhibition of the activity of nicotinamide phosphoribosyltransferase from various tissues of rats by NAD (1989), Agric. Biol. Chem., 53, 2283-2284.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 NAD+ 1 mM, 50%-90% inhibition in various tissues, at 0.2 mM not inhibitory in lung and liver; strong (thigh muscle) Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.12 Mg2+ requirement Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Rattus norvegicus
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Rattus norvegicus
-
 male Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 brain
-
 Rattus norvegicus
-
2.4.2.12 heart
-
 Rattus norvegicus
-
2.4.2.12 kidney
-
 Rattus norvegicus
-
2.4.2.12 liver
-
 Rattus norvegicus
-
2.4.2.12 lung
-
 Rattus norvegicus
-
2.4.2.12 additional information tissue distribution Rattus norvegicus
-
2.4.2.12 pancreas
-
 Rattus norvegicus
-
2.4.2.12 small intestine
-
 Rattus norvegicus
-
2.4.2.12 stomach
-
 Rattus norvegicus
-
2.4.2.12 testis
-
 Rattus norvegicus
-
2.4.2.12 thigh muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Rattus norvegicus nicotinamide D-ribonucleotide + diphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.12 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.4.2.12 ATP requirement Rattus norvegicus