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Literature summary extracted from

  • Shah, S.N.
    UDP-glucose: ceramide glucosyltransferase of rat brain: an association with smooth microsomes and requirement of an intact membrane for enzyme activity (1973), Arch. Biochem. Biophys., 159, 143-150.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.80 Detergents e.g. 0.5% Triton X-100 or 0.5% sodium deoxycholate; inhibition of enzyme due to permeabilization of microsomal membrane Rattus norvegicus
2.4.1.80 Phospholipase A treatment of microsomes results in loss of enzyme activity Rattus norvegicus
2.4.1.80 Phospholipase C treatment of microsomes results in loss of enzyme activity Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.80 membrane
-
Rattus norvegicus 16020
-
2.4.1.80 microsome associated with membranes, structural integrity of the microsomal membranes is essential for activity Rattus norvegicus
-
-
2.4.1.80 additional information enzyme is not associated with synaptosomes and myelin Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.80 UDP-glucose + N-acylsphingosine Rattus norvegicus catalyzes the first step during the sequential addition of carbohydrate moieties for ganglioside biosynthesis UDP + D-glucosyl-N-acylsphingosine
-
?
2.4.1.80 UDP-glucose + N-acylsphingosine Rattus norvegicus Sprague-Dawley catalyzes the first step during the sequential addition of carbohydrate moieties for ganglioside biosynthesis UDP + D-glucosyl-N-acylsphingosine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.80 Rattus norvegicus
-
Sprague-Dawley
-
2.4.1.80 Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.80 brain
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.80 additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.80 UDP-glucose + dihydrosphingosine dihydrosphingosine is no substrate Rattus norvegicus UDP + D-glucosyl-dihydrosphingosine
-
?
2.4.1.80 UDP-glucose + dihydrosphingosine dihydrosphingosine is no substrate Rattus norvegicus Sprague-Dawley UDP + D-glucosyl-dihydrosphingosine
-
?
2.4.1.80 UDP-glucose + N-acylsphingosine i.e. ceramide Rattus norvegicus UDP + D-glucosyl-N-acylsphingosine i.e. glucosylceramide ?
2.4.1.80 UDP-glucose + N-acylsphingosine catalyzes the first step during the sequential addition of carbohydrate moieties for ganglioside biosynthesis Rattus norvegicus UDP + D-glucosyl-N-acylsphingosine
-
?
2.4.1.80 UDP-glucose + N-acylsphingosine i.e. ceramide Rattus norvegicus Sprague-Dawley UDP + D-glucosyl-N-acylsphingosine i.e. glucosylceramide ?
2.4.1.80 UDP-glucose + N-acylsphingosine catalyzes the first step during the sequential addition of carbohydrate moieties for ganglioside biosynthesis Rattus norvegicus Sprague-Dawley UDP + D-glucosyl-N-acylsphingosine
-
?