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Literature summary extracted from

  • Ishibashi, T.; Kijimoto, S.; Makita, A.
    Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties of beta-N-acetyl-galactosaminyltransferase of guinea pig kidney (1974), Biochim. Biophys. Acta, 337, 92-106.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.79 nonionic detergents activation, e.g. Triton X-100 or CF-54 Cavia porcellus
2.4.1.79 Triton CF-54 activates Cavia porcellus
2.4.1.79 Triton X100 activates Cavia porcellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.79 EDTA 25 mM, 99% inhibition Cavia porcellus
2.4.1.79 GSH 2 mM, 17% inhibition Cavia porcellus
2.4.1.79 NaN3 2 mM, 38% inhibition Cavia porcellus
2.4.1.79 sodium deoxycholate
-
Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.79 0.14
-
D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
-
Cavia porcellus
2.4.1.79 0.23
-
UDP-N-acetylgalactosamine
-
Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.79 microsome
-
Cavia porcellus
-
-
2.4.1.79 mitochondrion
-
Cavia porcellus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.79 Mg2+ 18% as effective as Mn2+ in activation Cavia porcellus
2.4.1.79 Mn2+ required Cavia porcellus
2.4.1.79 Mn2+ optimal concentration: 10 mM Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.79 UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide Cavia porcellus enzyme is involved in globoside biosynthesis UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.79 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.79 brain
-
Cavia porcellus
-
2.4.1.79 kidney
-
Cavia porcellus
-
2.4.1.79 spleen
-
Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.79 UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
-
Cavia porcellus UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide globoside and Forssman hapten ?
2.4.1.79 UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
-
Cavia porcellus UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide i.e. globoside ?
2.4.1.79 UDP-N-acetyl-D-galactosamine + D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide enzyme is involved in globoside biosynthesis Cavia porcellus UDP + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
-
?
2.4.1.79 UDP-N-acetyl-D-galactosamine + disialoganglioside GD3
-
Cavia porcellus UDP + ?
-
?
2.4.1.79 UDP-N-acetyl-D-galactosamine + hematoside GM3 equine erythrocyte hematoside Cavia porcellus UDP + ?
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.79 6.9
-
-
Cavia porcellus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.1.79 5.5 8 about 50% of maximal activity at pH 5.5 and 8.0 Cavia porcellus