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Literature summary extracted from

  • Chandrasekaran, E.V.; Jain, R.K.; Larsen, R.D.; Wlasichuk, K.; Matta, K.L.
    Characterization of the specificities of human blood group H gene-specified alpha1,2-L-fucosyltransferase toward sulfated/sialylated/fucosylated acceptors: evidence for an inverse relationship between alpha1,2-L-fucosylation of Gal and alpha1,6-L-fucosylation of asparagine-linked GlcNAc (1996), Biochemistry, 35, 8914-8924.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.69 3-sulfoGalbeta(1,4)GlcNAcbeta(1,6)Galbeta(1,3)GalNAcalpha-O-benzyl
-
 Homo sapiens
2.4.1.69 Galbeta(1,3)GalNAcalpha-O-allyl
-
 Homo sapiens
2.4.1.69 Galbeta(1,4)GlcNAcbeta(1,6)3-sulfoGalbeta(1,3)-GalNAcalpha-O-benzyl
-
 Homo sapiens
2.4.1.69 Galbeta(1,4)GlcNAcbeta(1,6)Galbeta(1,3)-GalNAcalpha-O-benzyl
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.69 0.31
-
 Galbeta(1-3)GlcNAcbeta-O-allyl/acrylamide copolymer
-
 Homo sapiens
2.4.1.69 0.45
-
 6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl
-
 Homo sapiens
2.4.1.69 0.5
-
 fetuin triantennary asialoglycopeptide
-
 Homo sapiens
2.4.1.69 0.82
-
 Galbeta-O-benzyl
-
 Homo sapiens
2.4.1.69 0.83
-
 Galbeta(1-3)GlcNAcbeta-O-benzyl
-
 Homo sapiens
2.4.1.69 0.95
-
 GDP-L-fucose reaction with Galbeta(1-3)GalNAcalpha-O-allyl Homo sapiens
2.4.1.69 1
-
 bovine IgG diantennary glycopeptide
-
 Homo sapiens
2.4.1.69 1.33
-
 GDP-L-fucose reaction with Galbeta(1-3)GlcNAcbeta-O-allyl Homo sapiens
2.4.1.69 1.54
-
 GDP-L-fucose reaction with 6-sulfoGalbeta(1-3)GlcNAcbeta-O-allyl Homo sapiens
2.4.1.69 1.67
-
 Galbeta(1-4)GlcNAcbeta-O-benzyl
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.69 Homo sapiens
-
 recombinant and native enzyme
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.69 ovarian cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.69 GDP-L-fucose + 6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl
-
 Homo sapiens GDP + L-Fucalpha(1-2)6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl
-
 ?
2.4.1.69 GDP-L-fucose + beta-D-galactosyl-R detailed characterization of specificity Homo sapiens GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
 ?
2.4.1.69 GDP-L-fucose + bovine IgG diantennary glycopeptide
-
 Homo sapiens GDP + ?
-
 ?
2.4.1.69 GDP-L-fucose + fetuin triantennary asialoglycopeptide
-
 Homo sapiens GDP + ?
-
 ?
2.4.1.69 GDP-L-fucose + Galbeta(1-3)GlcNAcbeta-O-allyl/acrylamide copolymer
-
 Homo sapiens GDP + ?
-
 ?
2.4.1.69 GDP-L-fucose + Galbeta(1-3)GlcNAcbeta-O-benzyl
-
 Homo sapiens GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta-O-benzyl
-
 ?
2.4.1.69 GDP-L-fucose + Galbeta(1-4)GlcNAcbeta-O-benzyl
-
 Homo sapiens GDP + L-Fucalpha(1-2)Galbeta(1-4)GlcNAcbeta-O-benzyl
-
 ?
2.4.1.69 GDP-L-fucose + Galbeta-O-benzyl
-
 Homo sapiens GDP + L-Fucalpha(1-2)Galbeta-O-benzyl
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.69 6 8 enzyme from ovarian tumor Homo sapiens
2.4.1.69 7.2 7.6 recombinant enzyme Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.1.69 6 7.6 pH 6.0: 15% of maximal activity, pH 6.4: 59.2% of maximal activity, pH 6.8: 84.8% of maximal activity, pH 7.2-7.6: maximal activity, recombinant enzyme Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.69 5.6
-
 Galbeta(1,3)GalNAcalpha-O-allyl reaction with 6-sulfoGalbeta(1,3)GlcNAcbeta-O-allyl Homo sapiens
2.4.1.69 5.9
-
 Galbeta(1,4)GlcNAcbeta(1,6)Galbeta(1,3)-GalNAcalpha-O-benzyl reaction with 6-sulfoGalbeta(1,4)GlcNAcbeta-O-methyl Homo sapiens