EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.69 | NEM | - |
Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.69 | Ca2+ | 20 mM, 50% stimulation | Homo sapiens | |
2.4.1.69 | Mg2+ | stimulates to a maximum at 30 mM | Homo sapiens | |
2.4.1.69 | Mn2+ | stimulates to a maximum at 10 mM | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.69 | GDP-L-fucose + beta-D-galactosyl-R | Homo sapiens | enzyme is involved in expression of blood group H, Lewis b from Lewis a and Globo H | GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.69 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.1.69 | partial | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.69 | DU-145 cell | - |
Homo sapiens | - |
2.4.1.69 | PC-3 cell | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.4.1.69 | additional information | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.69 | GDP-L-fucose + beta-D-galactosyl-R | acceptor specificity, overview. C6-sulfation of terminal Gal in the LacNAc unit increases acceptor efficiency, C-6 sialylation abolishes acceptor ability, C6-sulfation of GlcNAc in LacNAc type 2 decreases by 80% the acceptor ability, whereas LacNAc type 1 is unaffected, the C-4 hydroxyl rather than the C-6 hydroxyl group of the GlcNAc moiety in LacNAc type 1 is essential for activity, the acrylamide copolymer of Galbeta(1-3)GlcNAcbeta-O-Al is the best acceptor among the acrylamide copolymers, Lewis x does not serve as an acceptor | Homo sapiens | GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R | - |
? | |
2.4.1.69 | GDP-L-fucose + beta-D-galactosyl-R | enzyme is involved in expression of blood group H, Lewis b from Lewis a and Globo H | Homo sapiens | GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.1.69 | 0.0125 | - |
NEM | - |
Homo sapiens |