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Literature summary extracted from

  • Chandrasekaran, E.V.; Chawda, R.; Locke, R.D.; Piskorz, C.F.; Matta, K.L.
    Biosynthesis of the carbohydrate antigenic determinants, Globo H, blood group H, and Lewis b: a role for prostate cancer cell alpha1,2-L-fucosyltransferase (2002), Glycobiology, 12, 153-162.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.69 NEM
-
Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.69 Ca2+ 20 mM, 50% stimulation Homo sapiens
2.4.1.69 Mg2+ stimulates to a maximum at 30 mM Homo sapiens
2.4.1.69 Mn2+ stimulates to a maximum at 10 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.69 GDP-L-fucose + beta-D-galactosyl-R Homo sapiens enzyme is involved in expression of blood group H, Lewis b from Lewis a and Globo H GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
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?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.69 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.69 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.69 DU-145 cell
-
Homo sapiens
-
2.4.1.69 PC-3 cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.69 additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.69 GDP-L-fucose + beta-D-galactosyl-R acceptor specificity, overview. C6-sulfation of terminal Gal in the LacNAc unit increases acceptor efficiency, C-6 sialylation abolishes acceptor ability, C6-sulfation of GlcNAc in LacNAc type 2 decreases by 80% the acceptor ability, whereas LacNAc type 1 is unaffected, the C-4 hydroxyl rather than the C-6 hydroxyl group of the GlcNAc moiety in LacNAc type 1 is essential for activity, the acrylamide copolymer of Galbeta(1-3)GlcNAcbeta-O-Al is the best acceptor among the acrylamide copolymers, Lewis x does not serve as an acceptor Homo sapiens GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
?
2.4.1.69 GDP-L-fucose + beta-D-galactosyl-R enzyme is involved in expression of blood group H, Lewis b from Lewis a and Globo H Homo sapiens GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.69 0.0125
-
NEM
-
Homo sapiens