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Literature summary extracted from

  • Leakey, J.E.A.
    An improved assay technique for uridine diphosphate glucuronosyltransferase activity towards 5-hydroxytryptamine and some properties of the enzyme (1978), Biochem. J., 175, 1119-1124.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 Diethylnitrosamine 5-10 fold increased activity towards o-aminophenol Rattus norvegicus
2.4.1.17 Digitonin
-
 Rattus norvegicus
2.4.1.17 Digitonin 7fold to 12fold increased activity Mus musculus
2.4.1.17 UDP-N-acetylglucosamine activation Mus musculus
2.4.1.17 UDP-N-acetylglucosamine activation Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Mus musculus
-
-
2.4.1.17 microsome
-
 Rattus norvegicus
-
-
2.4.1.17 microsome
-
 Felis catus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Felis catus
-
-
-
2.4.1.17 Mus musculus
-
-
-
2.4.1.17 Rattus norvegicus
-
 Wistar strain
-
2.4.1.17 Rattus norvegicus
-
 Gunn strain
-
2.4.1.17 Rattus norvegicus
-
 bilirubin UDP-glucuronosyltransferase not in Gunn strain
-
2.4.1.17 Rattus norvegicus
-
 distribution in Wistar and Gunn strain
-
2.4.1.17 Rattus norvegicus Gunn
-
 Gunn strain
-
2.4.1.17 Rattus norvegicus Gunn
-
 bilirubin UDP-glucuronosyltransferase not in Gunn strain
-
2.4.1.17 Rattus norvegicus Gunn
-
 distribution in Wistar and Gunn strain
-
2.4.1.17 Rattus norvegicus Wistar
-
 Wistar strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 duodenum
-
 Rattus norvegicus
-
2.4.1.17 kidney
-
 Mus musculus
-
2.4.1.17 kidney
-
 Rattus norvegicus
-
2.4.1.17 liver
-
 Mus musculus
-
2.4.1.17 liver
-
 Rattus norvegicus
-
2.4.1.17 liver
-
 Felis catus
-
2.4.1.17 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 bilirubin + UDPglucuronate Gunn strain liver enzyme inactive Rattus norvegicus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
2.4.1.17 bilirubin + UDPglucuronate cat liver enzyme active Felis catus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
2.4.1.17 bilirubin + UDPglucuronate Gunn strain liver enzyme inactive Rattus norvegicus Gunn bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
2.4.1.17 bilirubin + UDPglucuronate Gunn strain liver enzyme inactive Rattus norvegicus Wistar bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
2.4.1.17 serotonin + UDPglucuronate i.e. 5-hydroxytryptamine, liver enzyme inactive Felis catus tryptamine 5-O-beta-D-glucuronide + UDP
-
 ?
2.4.1.17 serotonin + UDPglucuronate Gunn strain liver enzyme active Rattus norvegicus tryptamine 5-O-beta-D-glucuronide + UDP
-
 ?
2.4.1.17 serotonin + UDPglucuronate Gunn strain liver enzyme active Rattus norvegicus Gunn tryptamine 5-O-beta-D-glucuronide + UDP
-
 ?
2.4.1.17 serotonin + UDPglucuronate Gunn strain liver enzyme active Rattus norvegicus Wistar tryptamine 5-O-beta-D-glucuronide + UDP
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.7
-
-
 Mus musculus