Literature summary extracted from

Causier, B.E.; Milling, R.J.; Foster, S.G.; Adams, D.J.
Characterization of chitin synthase from Botrytis cinerea (1994), Microbiology, 140, 2199-2205.

No PubMed abstract available

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.4.1.16	GlcNAc	stimulates	Botrytis cinerea

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.4.1.16	expression in Escherichia coli	Botrytis cinerea

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.4.1.16	edifenphos	non-competitive	Botrytis cinerea
2.4.1.16	nikkomycin Z	-	Botrytis cinerea
2.4.1.16	Polyoxin D	-	Botrytis cinerea
2.4.1.16	UDP	-	Botrytis cinerea

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.4.1.16	2	-	UDP-GlcNAc	-	Botrytis cinerea

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
2.4.1.16	Mn2+	dependent upon presence of divalent cation, Mn2+ is most effective	Botrytis cinerea

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.16	Botrytis cinerea	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
2.4.1.16	proteolytic modification	preincubation with trypsin results in approximately 4fold increase in activity	Botrytis cinerea

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.1.16	UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n	-	Botrytis cinerea	UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1	-	?

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
2.4.1.16	35	-	-	Botrytis cinerea

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.4.1.16	0.0001	-	nikkomycin Z	-	Botrytis cinerea
2.4.1.16	0.006	-	Polyoxin D	-	Botrytis cinerea
2.4.1.16	0.054	-	edifenphos	-	Botrytis cinerea
2.4.1.16	0.19	-	UDP	-	Botrytis cinerea

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Release 2023.1 (January 2023)