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Literature summary extracted from

  • Gow, L.A.; Selitrennikoff, C.P.
    Chitin synthetase of Neurospora crassa: inhibition by nikkomycin, polyoxin B, and UDP (1984), Curr. Microbiol., 11, 211-216.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.16 GlcNAc Km: 3.9 mM Neurospora crassa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.16 Nikkomycin linear competitive inhibitor Neurospora crassa
2.4.1.16 Polyoxin B
-
 Neurospora crassa
2.4.1.16 Polyoxin D linear competitive inhibitor Neurospora crassa
2.4.1.16 UDP linear competitive inhibitor Neurospora crassa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.16 Mg2+ 8-20 mM, 6fold stimulation Neurospora crassa

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.16 Neurospora crassa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.16 UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Neurospora crassa UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.16 7.5
-
 Hepes buffer Neurospora crassa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.16 0.002
-
 Nikkomycin
-
 Neurospora crassa
2.4.1.16 0.032
-
 Polyoxin B
-
 Neurospora crassa
2.4.1.16 0.8
-
 UDP
-
 Neurospora crassa