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Literature summary extracted from

  • Pan, Y.T.; Elbein, A.D.
    Inhibition of the trehalose-P synthase of mycobacteria by various antibiotics (1996), Arch. Biochem. Biophys., 335, 258-266.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.15 cathomycin competitive inhibition, inhibits reaction with either UDPglucose or GDPglucose as glucosyl donor. Preincubation with heparin prevents inhibition. 0.05 mg/ml-0.2 mg/ml: 50% inhibition Mycolicibacterium smegmatis
2.4.1.15 circulin noncompetitive inhibition, inhibits reaction with either UDPglucose or GDPglucose as glucosyl donor. Preincubation with heparin prevents inhibition. 0.05 mg/ml-0.2 mg/ml: 50% inhibition Mycolicibacterium smegmatis
2.4.1.15 Diumycin competitive inhibition, inhibits reaction with either UDPglucose or GDPglucose as glucosyl donor. Preincubation with heparin prevents inhibition. 0.05 mg/ml: 50% inhibition Mycolicibacterium smegmatis
2.4.1.15 Moenomycin competitive inhibition, inhibits reaction with either UDPglucose or GDPglucose as glucosyl donor. Preincubation with heparin prevents inhibition. Preincubation with heparin prevents inhibition. 0.05 mg/ml: 50% inhibition Mycolicibacterium smegmatis

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.15 Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.15 GDP-glucose + D-glucose 6-phosphate
-
 Mycolicibacterium smegmatis trehalose 6-phosphate + GDP
-
 ?
2.4.1.15 UDPglucose + glucose 6-phosphate
-
 Mycolicibacterium smegmatis trehalose 6-phosphate + UDP
-
 ?