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Literature summary extracted from

  • Kaplan, H.A.; Welply, J.K.; Lennarz, W.J.
    Oligosaccharyl transferase: the central enzyme in the pathway of glycoprotein assembly (1987), Biochim. Biophys. Acta, 906, 161-173.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.99.18 rough endoplasmic reticulum integral membrane protein, tightly associated to luminal side of membrane Gallus gallus 5791
-
2.4.99.18 rough endoplasmic reticulum integral membrane protein, tightly associated to luminal side of membrane Drosophila melanogaster 5791
-
2.4.99.18 rough endoplasmic reticulum integral membrane protein, tightly associated to luminal side of membrane Mus musculus 5791
-
2.4.99.18 rough endoplasmic reticulum integral membrane protein, tightly associated to luminal side of membrane Rattus norvegicus 5791
-
2.4.99.18 rough endoplasmic reticulum integral membrane protein, tightly associated to luminal side of membrane Saccharomyces cerevisiae 5791
-
2.4.99.18 rough endoplasmic reticulum integral membrane protein, tightly associated to luminal side of membrane Oryctolagus cuniculus 5791
-
2.4.99.18 rough endoplasmic reticulum integral membrane protein, tightly associated to luminal side of membrane Canis lupus familiaris 5791
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.99.18 60000
-
 x * 60000, SDS-PAGE Gallus gallus
2.4.99.18 80000
-
 x * 80000, SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain Gallus gallus central enzyme in the pathway of glycoprotein assembly ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain Drosophila melanogaster central enzyme in the pathway of glycoprotein assembly ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain Mus musculus central enzyme in the pathway of glycoprotein assembly ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain Rattus norvegicus central enzyme in the pathway of glycoprotein assembly ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain Saccharomyces cerevisiae central enzyme in the pathway of glycoprotein assembly ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain Oryctolagus cuniculus central enzyme in the pathway of glycoprotein assembly ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain Canis lupus familiaris central enzyme in the pathway of glycoprotein assembly ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.99.18 Canis lupus familiaris
-
-
-
2.4.99.18 Drosophila melanogaster
-
-
-
2.4.99.18 Gallus gallus
-
 hen
-
2.4.99.18 Mus musculus
-
-
-
2.4.99.18 Oryctolagus cuniculus
-
-
-
2.4.99.18 Rattus norvegicus
-
-
-
2.4.99.18 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.99.18
-
 Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.99.18 brain
-
 Gallus gallus
-
2.4.99.18 FAZA cell hepatoma cell line Rattus norvegicus
-
2.4.99.18 intestine
-
 Gallus gallus
-
2.4.99.18 kidney
-
 Gallus gallus
-
2.4.99.18 liver
-
 Gallus gallus
-
2.4.99.18 liver
-
 Mus musculus
-
2.4.99.18 liver
-
 Rattus norvegicus
-
2.4.99.18 oviduct
-
 Gallus gallus
-
2.4.99.18 pancreas
-
 Canis lupus familiaris
-
2.4.99.18 uterus
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine peptide acceptor specificity Gallus gallus dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine peptide acceptor specificity Drosophila melanogaster dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine peptide acceptor specificity Mus musculus dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine peptide acceptor specificity Rattus norvegicus dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine peptide acceptor specificity Saccharomyces cerevisiae dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine peptide acceptor specificity Oryctolagus cuniculus dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine peptide acceptor specificity Canis lupus familiaris dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine catalyzes reaction between beta-amido nitrogen of Asn-residue and oligosaccharyl-diphosphodolichol Gallus gallus dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine catalyzes reaction between beta-amido nitrogen of Asn-residue and oligosaccharyl-diphosphodolichol Drosophila melanogaster dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine catalyzes reaction between beta-amido nitrogen of Asn-residue and oligosaccharyl-diphosphodolichol Mus musculus dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine catalyzes reaction between beta-amido nitrogen of Asn-residue and oligosaccharyl-diphosphodolichol Rattus norvegicus dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine catalyzes reaction between beta-amido nitrogen of Asn-residue and oligosaccharyl-diphosphodolichol Saccharomyces cerevisiae dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine catalyzes reaction between beta-amido nitrogen of Asn-residue and oligosaccharyl-diphosphodolichol Oryctolagus cuniculus dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 dolichyl diphosphooligosaccharide + protein L-asparagine catalyzes reaction between beta-amido nitrogen of Asn-residue and oligosaccharyl-diphosphodolichol Canis lupus familiaris dolichyl diphosphate + glycoprotein with the oligosaccharide chain attached by N-glycosyl-linkage to protein L-asparagine
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain central enzyme in the pathway of glycoprotein assembly Gallus gallus ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain central enzyme in the pathway of glycoprotein assembly Drosophila melanogaster ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain central enzyme in the pathway of glycoprotein assembly Mus musculus ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain central enzyme in the pathway of glycoprotein assembly Rattus norvegicus ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain central enzyme in the pathway of glycoprotein assembly Saccharomyces cerevisiae ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain central enzyme in the pathway of glycoprotein assembly Oryctolagus cuniculus ?
-
 ?
2.4.99.18 lipid-linked oligosaccharide + unfolded nascent polypeptide chain central enzyme in the pathway of glycoprotein assembly Canis lupus familiaris ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.99.18 ?
-
 Canis lupus familiaris
2.4.99.18 ? x * 80000, SDS-PAGE Saccharomyces cerevisiae
2.4.99.18 ? x * 60000, SDS-PAGE Gallus gallus