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Literature summary extracted from

  • Itarte, E.; Castineiras, M.J.; Guinovart, J.J.; Prerz, M.R.
    Interconversion and characterization of D and I forms of glycogen synthase from frog muscle (1978), Biochim. Biophys. Acta, 524, 305-315.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.11 2-deoxyglucose 6-phosphate stimulates interconversion of D to I form Pelophylax ridibundus
2.4.1.11 galactose 6-phosphate stimulates interconversion of D to I form Pelophylax ridibundus
2.4.1.11 glucosamine 6-phosphate stimulates interconversion of D to I form Pelophylax ridibundus
2.4.1.11 glucose 6-phosphate synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa Pelophylax ridibundus
2.4.1.11 glucose 6-phosphate stimulates at UDP-glucose concentration of 0.4 mM Pelophylax ridibundus
2.4.1.11 phosphate below 2 mM Pelophylax ridibundus
2.4.1.11 ribose 5-phosphate stimulates interconversion of D to I form Pelophylax ridibundus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.11 ATP
-
 Pelophylax ridibundus
2.4.1.11 Mg2+ above 2 mM Pelophylax ridibundus
2.4.1.11 phosphate high concentrations Pelophylax ridibundus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.11 Ca2+ stimulates interconversion of D to I from Pelophylax ridibundus
2.4.1.11 Mg2+ stimulates D form but not I form Pelophylax ridibundus
2.4.1.11 Mn2+ stimulates interconversion of D to I form Pelophylax ridibundus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen Pelophylax ridibundus
-
 glycogen + UDP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.11 Pelophylax ridibundus
-
 frog
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.11 phosphoprotein
-
 Pelophylax ridibundus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.11 leg muscle
-
 Pelophylax ridibundus
-
2.4.1.11 muscle
-
 Pelophylax ridibundus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen
-
 Pelophylax ridibundus glycogen + UDP
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.11 7.8
-
-
 Pelophylax ridibundus