EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.3.5 | isocitrate | 1 mM, relative activity 101% | Yarrowia lipolytica |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.3.5 | ADP | slight inhibition | Yarrowia lipolytica | |
2.3.3.5 | ATP | - |
Yarrowia lipolytica | |
2.3.3.5 | H2O2 | - |
Yarrowia lipolytica | |
2.3.3.5 | Hg2+ | - |
Yarrowia lipolytica | |
2.3.3.5 | Monoiodoacetamide | - |
Yarrowia lipolytica | |
2.3.3.5 | NADH | - |
Yarrowia lipolytica | |
2.3.3.5 | NADPH | - |
Yarrowia lipolytica | |
2.3.3.5 | p-chloromercuribenzoate | - |
Yarrowia lipolytica | |
2.3.3.5 | Zn2+ | - |
Yarrowia lipolytica |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.3.5 | 0.0029 | - |
acetyl-CoA | - |
Yarrowia lipolytica | |
2.3.3.5 | 0.0053 | - |
propionyl-CoA | - |
Yarrowia lipolytica | |
2.3.3.5 | 0.022 | - |
butyryl-CoA | - |
Yarrowia lipolytica | |
2.3.3.5 | 0.025 | - |
oxaloacetate | - |
Yarrowia lipolytica | |
2.3.3.5 | 0.025 | - |
valeryl-CoA | - |
Yarrowia lipolytica |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.3.3.5 | Ca2+ | 1 mM, relative activity 104% | Yarrowia lipolytica | |
2.3.3.5 | Fe2+ | 0.02 mM, relative activity 104% | Yarrowia lipolytica | |
2.3.3.5 | Mg2+ | 1 mM, relative activity 102% | Yarrowia lipolytica |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate | Yarrowia lipolytica | physiological role of the methylcitric acid cycle is a catabolic reaction sequence concerning the oxidation of propionate into pyruvate, regulatory enzyme of this cycle | 2-methylcitrate + CoA | - |
? | |
2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate | Escherichia coli | first key enzyme of the methylcitric acid cycle | 2-methylcitrate + CoA | - |
? | |
2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate | Yarrowia lipolytica | first key enzyme of the methylcitric acid cycle | 2-methylcitrate + CoA | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.3.5 | Escherichia coli | - |
- |
- |
2.3.3.5 | Yarrowia lipolytica | - |
formerly Candida lipolytica | - |
2.3.3.5 | Yarrowia lipolytica | - |
IFO 1659 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.3.5 | - |
Yarrowia lipolytica |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.3.5 | 0.436 | - |
substrate propionyl-CoA | Yarrowia lipolytica |
2.3.3.5 | 0.623 | - |
substrate acetyl-CoA | Yarrowia lipolytica |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.3.5 | acetyl-CoA + H2O + oxaloacetate | - |
Yarrowia lipolytica | citrate + CoA | - |
? | |
2.3.3.5 | additional information | enzyme is specific for oxaloacetate, does not catalyze liberation of CoA from acetyl- or propionyl-CoA in presence of glyoxylate, pyruvate or alpha-ketoglutarate, isobutyryl-CoA and isovaleryl-CoA are no substrates | Yarrowia lipolytica | ? | - |
? | |
2.3.3.5 | n-butyryl-CoA + H2O + oxaloacetate | - |
Yarrowia lipolytica | 2-ethylcitrate + CoA | - |
r | |
2.3.3.5 | n-valeryl-CoA + H2O + oxaloacetate | - |
Yarrowia lipolytica | 2-propylcitrate + CoA | - |
r | |
2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate | - |
Escherichia coli | 2-methylcitrate + CoA | - |
? | |
2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate | - |
Yarrowia lipolytica | 2-methylcitrate + CoA | - |
? | |
2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate | physiological role of the methylcitric acid cycle is a catabolic reaction sequence concerning the oxidation of propionate into pyruvate, regulatory enzyme of this cycle | Yarrowia lipolytica | 2-methylcitrate + CoA | - |
? | |
2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate | first key enzyme of the methylcitric acid cycle | Escherichia coli | 2-methylcitrate + CoA | - |
? | |
2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate | first key enzyme of the methylcitric acid cycle | Yarrowia lipolytica | 2-methylcitrate + CoA | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.3.5 | 45 | - |
- |
Yarrowia lipolytica |
EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.3.5 | 10 | 50 | - |
Yarrowia lipolytica |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.3.5 | 50 | - |
activity completely lost after 10 min | Yarrowia lipolytica |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.3.5 | 8 | 8.5 | - |
Yarrowia lipolytica |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.3.3.5 | 6 | 9.5 | - |
Yarrowia lipolytica |