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Literature summary extracted from

  • Montamat, F.; Guilloton, M.; Karst, F.; Delrot, S.
    Isolation and characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl-coenzyme A synthase (1995), Gene, 167, 197-201.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.3.10 cDNA cloned by complementation of a bap1 mutation and expressed in Saccharomyces cerevisiae Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.3.10 membrane
-
 Arabidopsis thaliana 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.3.10 51040
-
 predicted from cDNA sequence Arabidopsis thaliana
2.3.3.10 55500
-
 SDS-PAGE Arabidopsis thaliana
2.3.3.10 57250
-
 deduced amino acid sequence Cricetulus griseus
2.3.3.10 57290
-
 deduced amino acid sequence Homo sapiens
2.3.3.10 57370
-
 deduced amino acid sequence Rattus norvegicus
2.3.3.10 57490
-
 deduced amino acid sequence Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Gallus gallus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Cricetulus griseus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Homo sapiens
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Rattus norvegicus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Raphanus sativus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Catharanthus roseus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Arabidopsis thaliana key role in synthesis of various sterols and isoprenoids (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.10 Arabidopsis thaliana
-
-
-
2.3.3.10 Catharanthus roseus
-
-
-
2.3.3.10 Cricetulus griseus
-
 chinese hamster
-
2.3.3.10 Gallus gallus
-
 chicken
-
2.3.3.10 Homo sapiens
-
 human
-
2.3.3.10 Raphanus sativus
-
 radish
-
2.3.3.10 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.3.10
-
 Arabidopsis thaliana

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.3.10 fibroblast
-
 Homo sapiens
-
2.3.3.10 liver
-
 Gallus gallus
-
2.3.3.10 liver
-
 Rattus norvegicus
-
2.3.3.10 ovary
-
 Cricetulus griseus
-
2.3.3.10 seedling
-
 Raphanus sativus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Gallus gallus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Cricetulus griseus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Homo sapiens (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Rattus norvegicus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Arabidopsis thaliana (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Raphanus sativus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Catharanthus roseus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O key role in synthesis of various sterols and isoprenoids Arabidopsis thaliana (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?